528609-84-9

Upstream product

• 115269-21-1 (2R,6S)-4-oxatricyclo[5.2.1.0^2,6]dec-8-en-3-one 
• 528609-67-8 (R)-1-((1S,2R,3S,4R)-3-Hydroxymethyl-bicyclo[2.2.1]hept-5-en-2-yl)-1-phenyl-ethanol 

Downstream Products

• 52264-92-3 (+)-(R)-5-methyl-5-phenylfuran-2(5H)-one 

Relevant academic research and scientific papers

Enantiodivergent syntheses of γ-substituted butenolides with tertiary and quaternary asymmetric centers

Continuous nucleophilic addition with several organometallic reagents to tricyclic lactone (-)-1 proceeded diastereoselectively. Newly generated tertiary and quaternary asymmetric centers were controlled by the order in which the nucleophilic reagents were added. Using this methodology, enantiodivergent syntheses of several γ-substituted butenolides with tertiary and quaternary asymmetric centers were established from a single chiral material.