52864-54-7

Upstream product

• 33924-45-7 2-bromo-4-chlorobenzyl bromide 
• 143-33-9 sodium cyanide 
• 1202889-66-4 2-bromo-4-chloro-1-(dibromomethyl)benzene 
• 84459-33-6 2-bromo-4-chlorobenzaldehyde 
• 143888-84-0 (2-bromo-4-chloro-phenyl)methanol 
• 773837-37-9 sodium cyanide 

Downstream Products

• 52864-55-8 Ethyl-2-brom-4-chlorphenylacetat 
• 874285-02-6 2-(4-chloro-2-methoxyphenyl)ethanamine 
• 1616925-25-7 9-benzyloxy-6-(4-chloro-2-pyridin-3-ylbenzyl)-2-isopropyl-3,4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dione 

Relevant academic research and scientific papers

FACTOR XIA-INHIBITING PYRIDOBENZAZEPINE AND PYRIDOBENZAZOCINE DERIVATIVES

The invention relates to substituted pyridobenzazepine and pyridobenzazocine derivatives and to processes for preparation thereof, and also to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially of cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.

Gold-catalyzed 1,2-oxoarylations of nitriles with pyridine-derived oxides

We report the first success in the gold-catalyzed oxoarylations of nitriles with pyridine-derived N-oxides using gold carbenes as initiators. These oxoarylations were also achieved satisfactorily in intermolecular three-component oxidations, including diverse alkenyldiazo esters, nitriles, and pyridine-based oxides. Spill the (car)benes: Reported herein is the first successful gold-catalyzed oxoarylation of nitriles with pyridine-derived N-oxides using gold carbenes as initiators (see scheme; DCE=1,2-dichloroethane, IPr=1,3-bis(diisopropylphenyl)imidazol-2-ylidene). These oxoarylations were also achieved satisfactorily in intermolecular three-component oxidations using a variety of alkenyldiazo esters, nitriles, and pyridine-based N-oxides.

6-SUBSTITUTED PHENOXYCHROMAN CARBOXYLIC ACID DERIVATIVES

Compounds of Formula (I): in which A1, A2, W, L, G, R7a, R7b, R8, R9 and R10 have the meanings given in the specification, are DP2 receptor modulators useful in the treatment of immunologic diseases.