528839-06-7

Upstream product

• 528839-05-6 (6R,7R)-7-[2-(4-tert-Butoxycarbonylmethylsulfanyl-2,5-dichloro-phenylsulfanyl)-acetylamino]-3-chloromethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 3773-14-6 2,4,5-trichlorothiophenol 
• 208512-64-5 (2,5-dichloro-4-methoxycarbonylmethylsulfanyl-benzenesulfinyl)-acetic acid tert-butyl ester 
• 415926-82-8 (4-tert-butoxycarbonylmethylsulfanyl-2,5-dichloro-phenylsulfanyl)-acetic acid 
• 208512-70-3 (2,5-dichloro-4-methoxycarbonylmethylsulfanyl-phenylsulfanyl)-acetic acid tert-butyl ester 
• 208512-62-3 (2,4,5-trichloro-benzenesulfinyl)-acetic acid tert-butyl ester 
• 208512-60-1 (2,4,5-trichloro-phenylsulfanyl)-acetic acid tert-butyl ester 

Relevant academic research and scientific papers

Anti-MRSA cephems. Part 3: additional C-7 acid derivatives.

Twenty-seven novel cephalosporin derivatives with activity against methicillin-resistant Staphylococcus aureus (MRSA) are described. The compounds contain novel acid moieties at C-7 that were synthesized using nucleophilic aromatic substitution reactions and Stille couplings. The most interesting compound (6) displayed an MIC(90) against MRSA of 3.7 microg/mL, and an average PD(50) of 3.9 mg/kg.