528882-09-9

Basic information

• Product Name: 3H-1,3,4-Benzotriazepine-3-acetic acid, 5-cyclohexyl-1,2-dihydro-2-oxo-, ethyl ester
• CAS NO: 528882-09-9
• Molecular Formula: C18H23N3O3
• Molecular Weight: 329.399
• Mol File: 528882-09-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 3H-1,3,4-Benzotriazepine-3-acetic acid, 5-cyclohexyl-1,2-dihydro-2-oxo-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3H-1,3,4-Benzotriazepine-3-acetic acid, 5-cyclohexyl-1,2-dihydro-2-oxo-, ethyl ester(528882-09-9)
• EPA Substance Registry System: 3H-1,3,4-Benzotriazepine-3-acetic acid, 5-cyclohexyl-1,2-dihydro-2-oxo-, ethyl ester(528882-09-9)

Safety Data

• Hazardous Substances Data: 528882-09-9(Hazardous Substances Data)

Upstream product

• 929710-13-4 [1-[[[2-(cyclohexylcarbonyl)-phenyl]-amino]-carbonyl]-hydrazino]-acetic acid ethyl ester 
• 3432-87-9 (2-aminophenyl)cyclohexylmethanone 
• 6945-92-2 2-hydrazinyl acetic acid ethyl ester hydrochloride 
• 528882-08-8 (N'-((2-amino-phenyl)-cyclohexyl-methylene)-hydrazino)acetic acid ethyl ester 
• 32315-10-9 bis(trichloromethyl) carbonate 

Downstream Products

• 528882-54-4 (5-cyclohexyl-1-(2-oxo-propyl)-2-oxo-1,2-dihydro-3H-1,3,4-benzotriazepin-3-yl)-acetic acid ethyl ester 
• 942232-32-8 C₂₃H₃₃N₃O₃ 
• 942232-33-9 C₂₄H₃₂N₄O₄ 
• 942232-34-0 C₂₂H₃₁N₃O₄ 
• 942232-35-1 C₃₀H₃₉N₃O₄ 
• 942232-36-2 C₂₇H₃₁N₃O₄ 
• 929710-14-5 [5-cyclohexyl-1-(2-cyclopentyl-2-oxo-ethyl)-2-oxo-1,2-dihydro-benzo[e][1,2,4]triazepin-3-yl]-acetic acid ethyl ester 
• 942232-37-3 C₂₆H₃₅N₃O₄ 
• 942232-38-4 C₂₆H₃₅N₃O₄ 
• 942232-31-7 C₁₉H₂₅N₃O₃ 
• 916505-13-0 [5-cyclohexyl-1-(4-nitro-phenyl)-2-oxo-1,2-dihydro-3H-1,3,4-benzotriazepin-3-yl]-acetic acid ethyl ester 
• 528882-17-9 (3-{2-[5-cyclohexyl-1-(3,3-dimethyl-2-oxo-butyl)-2-oxo-1,2-dihydro-3H-1,3,4-benzotriazepin-3-yl]-acetylamino}-phenyl)-methyl-carbamic acid tert-butyl ester 
• 528882-66-8 2-[5-cyclohexyl-1-(3,3-dimethyl-2-oxo-butyl)-2-oxo-1,2-dihydro-3H-1,3,4-benzotriazepin-3-yl]-N-(3-pyrrolidin-1-yl-phenyl)-acetamide 
• 528883-05-8 (3-(2-(5-cyclohexyl-1,2-dihydro-1-(3,3-dimethyl-2-oxo-butyl)-2-oxo-1,2-dihydro-3H-1,3,4-benzotriazepin-3-yl)acetamido)phenyl)methyl methyl carbonate 

Relevant articles and documents

PROCESS FOR THE PREPARATION OF BENZOTRIAZEPINE DERIVATIVES

The present invention is directed to a novel process for the preparation of benzo[e][1,2,4]triazepin-2-one derivatives, useful in the preparation of gastrin and cholecystokinin receptor ligands.

Novel, achiral 1,3,4-benzotriazepine analogues of 1,4-benzodiazepine-based CCK2 antagonists that display high selectivity over CCK1 receptors

A series of 1,3,4-benzotriazepine-based CCK2 antagonists have been devised by consideration of the structural features that govern CCK receptor affinity and the receptor subtype selectivity of 1,4-benzodiazepine- based CCK2 antagonists. In contrast to the latter compounds, these novel 1,3,4-benzotriazepines are achiral, yet they display similar affinity for CCK2 receptors to the earlier molecules and are highly selective over CCK1 receptors.

BENZOTRIAZEPINE DERIVATIVES AND THEIR USE AS GASTRIN AND CHOLECYSTOKININ RECEPTOR LIGANDS

This invention relates to a compound of formula (I). The compound is useful for the treatment of gastrin related disorders.