528882-15-7

Basic information

• Product Name: tert-Butyl methyl(3-nitrophenyl)carbamate
• Synonyms: tert-Butyl methyl(3-nitrophenyl)carbamate;tert-butyl N-methyl-N-(3-nitrophenyl)carbamate;tert-Butyl methyl(3-nitrophenyl)carbamate (Related Reference)
• CAS NO: 528882-15-7
• Molecular Formula: C₁₂H₁₆N₂O₄
• Molecular Weight: 252.27
• Mol File: 528882-15-7.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 348.63°C at 760 mmHg
• Flash Point: 164.646°C
• Appearance: /
• Density: 1.208g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.559
• CAS DataBase Reference: tert-Butyl methyl(3-nitrophenyl)carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-Butyl methyl(3-nitrophenyl)carbamate(528882-15-7)
• EPA Substance Registry System: tert-Butyl methyl(3-nitrophenyl)carbamate(528882-15-7)

Safety Data

• Hazardous Substances Data: 528882-15-7(Hazardous Substances Data)

Usage

General Description

Tert-Butyl methyl(3-nitrophenyl)carbamate is a chemical compound often used in scientific research applications. Its molecular formula is C12H16N2O4, and it’s characterized by a molecular weight of approximately 248.26 g/mol. Like most carbamates, it is derived from carbamic acid and holds potential as an insecticidal agent due to its ability to inhibit acetylcholinesterase, an essential enzyme found in the nervous system of insects. However, its specific functions and uses may vary depending on the experimental or industrial context. Its hazard and safety information should be referred to before handling and use.

InChI:InChI=1/C12H16N2O4/c1-12(2,3)18-11(15)13(4)9-6-5-7-10(8-9)14(16)17/h5-8H,1-4H3

Upstream product

• 18437-64-4 tert-butyl (3-nitrophenyl)carbamate 
• 77-78-1 dimethyl sulfate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 619-26-1 N-methyl-3-nitroaniline 
• 74-88-4 methyl iodide 
• 3320-87-4 isocyanic acid (3-nitro-phenyl) ester 

Downstream Products

• 1228465-61-9 N-{5-[(3-{[(4-tert-butylphenyl)carbamoyl]amino}phenyl)(methyl)amino][1,3]thiazolo[5,4-b]pyridin-2-yl}cyclopropanecarboxamide 
• 1228466-13-4 tert-butyl methyl{3-[(trifluoroacetyl)amino]phenyl}carbamate 
• 1228466-14-5 2,2,2-trifluoro-N-[3-(methylamino)phenyl]acetamide 
• 1228466-15-6 2,2,2-trifluoro-N-{3-[methyl(5-nitropyridin-2-yl)amino]phenyl}acetamide 
• 1228466-17-8 N-{3-[(2-amino[1,3]thiazolo[5,4-b]pyridin-5-yl)(methyl)amino]phenyl}-2,2,2-trifluoroacetamide 
• 1228531-94-9 N-[3-[(5-aminopyridin-2-yl)(methyl)amino]phenyl]-2,2,2-trifluoroacetamide 
• 1228466-18-9 N-[5-(methyl{3-[(trifluoroacetyl)amino]phenyl}amino)[1,3]thiazolo[5,4-b]pyridin-2-yl]cyclopropanecarboxamide 
• 1228466-19-0 N-{5-[(3-aminophenyl)(methyl)amino][1,3]thiazolo[5,4-b]pyridin-2-yl}cyclopropanecarboxamide 
• 1228465-62-0 N-(5-{methyl[3-({[4-(trifluoromethoxy)phenyl]carbamoyl}amino)phenyl]amino}[1,3]thiazolo[5,4-b]pyridin-2-yl)cyclopropanecarboxamide 
• 1228465-64-2 N-(5-{[3-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenyl](methyl)amino}[1,3]thiazolo[5,4-b]pyridin-2-yl)cyclopropanecarboxamide 
• 1228465-63-1 N-(5-{methyl[3-({[4-(trifluoromethyl)phenyl]carbamoyl}amino)phenyl]amino}[1,3]thiazolo[5,4-b]pyridin-2-yl)cyclopropanecarboxamide 
• 1448444-64-1 tert-butyl 3-(6-(dibenzylamino)-5-nitropyrimidin-4-ylamino)phenyl(methyl)carbamate 
• 1448444-65-2 tert-butyl 3-(5-amino-6-(dibenzylamino)pyrimidin-4-ylamino)phenyl(methyl)carbamate 
• 1448444-66-3 tert-butyl 3-(6-(dibenzylamino)-8-oxo-7H-purin-9(8H)-yl)phenyl(methyl)carbamate 

Relevant articles and documents

FUSED PYRIMIDINE COMPOUNDS, COMPOSITIONS AND MEDICINAL APPLICATIONS THEREOF

The present disclosure relates to a class of fused pyrimidine compounds of Formula I, their stereoisomers, tautomers, pharmaceutically acceptable salts, polymorphs, solvates, and hydrates thereof. The present disclosure also relates to a process of preparation of these fused pyrimidine compounds, and to pharmaceutical compositions containing them.

COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 4 POLYPEPTIDES

The present disclosure relates to bifunctional compounds, which find utility as modulators of Interleukin-1 Receptor-Associated Kinase 4 (IRAK-4); the target protein). In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a Von Hppel-Lindau, cereblon, ligand which binds to the E3 ubiquitin ligase and on the other end a moiety which binds the target protein, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The present disclosure exhibits a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aggregation or accumulation of the target protein are treated or prevented with compounds and compositions of the present disclosure.

HETEROARYL COMPOUNDS AND USES THEREOF

The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.