528894-02-2

Basic information

• Product Name: 3-((1S,2S)-1-Benzyloxycarbonyl-2-methyl-butyl)-imidazolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester
• CAS NO: 528894-02-2
• Molecular Weight: 498.622
• Mol File: 528894-02-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-((1S,2S)-1-Benzyloxycarbonyl-2-methyl-butyl)-imidazolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-((1S,2S)-1-Benzyloxycarbonyl-2-methyl-butyl)-imidazolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester(528894-02-2)
• EPA Substance Registry System: 3-((1S,2S)-1-Benzyloxycarbonyl-2-methyl-butyl)-imidazolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester(528894-02-2)

Safety Data

• Hazardous Substances Data: 528894-02-2(Hazardous Substances Data)

Upstream product

• 156939-65-0 (9H-fluoren-9-yl)methyl (2-(methoxy(methyl)amino)-2-oxoethyl)carbamate 
• 156939-62-7 (9H-fluoren-9-yl)methyl(2-oxoethyl)carbamate 
• 29022-11-5 N-(fluoren-9-ylmethoxycarbonyl)glycine 
• 50-00-0 formaldehyd 
• 528894-01-1 Fmoc-Gly-α[CH2NH]-Ile-O-Bzl 
• 42406-72-4 L-isoleucine benzyl ester 

Downstream Products

• 528894-03-3 (2S,3S)-2-{3-[2-(9H-Fluoren-9-ylmethoxycarbonylamino)-acetyl]-imidazolidin-1-yl}-3-methyl-pentanoic acid benzyl ester 

Relevant articles and documents

Facile synthesis and cleavage of imidazolidines in a novel protection strategy for the preparation of peptides containing a reduced amide bioisostere

Unsymmetrical imidazolidines were obtained in 75-91% yield by treating monoalkoxycarbonyl vicinal diamines at room temperature with aqueous 37% formaldehyde in the presence of Montmorillonite KSF as a solid catalyst. The imidazolidines were shown to be useful intermediates in a novel protection strategy for the synthesis of peptide analogues containing a reduced glycine amide bioisostere. The imidazolidine intermediate was cleaved conveniently and efficiently by 50% TFA in methylene chloride.