52909-79-2Relevant academic research and scientific papers
A simple and fast synthetic pathway of β-Enamino-esters by condensation of β-Keto ester with aliphatic and aromatic amines in ethanol
Kouadri,Ouahrani,Missaoui,Chebrouk,Gherraf
, p. 2575 - 2578 (2015)
The β-keto ester undergoes condensation reactions with aliphatic and aromatic amines in ethanol to give high-yielding β-enamino ester. The method is simple, cost-effective and environmentally benign. Structural characterization of the synthesized compound
Silica Gel-mediated Synthesis of β-Enamino Esters and its Application for the Synthesis of Indeno 4-Hydroxypyridin-2(1H)-Ones
Kim, Soong-Hyun,Bae, Seri,Ko, Eun Bi,Park, Ga Young,Lee, Eunhye,Hwang, Hee Jong,Im, Chun Young,Song, Minsoo
, p. 262 - 269 (2019/02/09)
The full scope of SiO2-based condensation of aliphatic or aromatic amines and β-keto esters to give β-enamino esters was examined. Functionalized linear β-enamino esters were easily obtained from SiO2-based condensation of β-keto esters and amines only after simple filtration. It was also demonstrated that cyclic β-enamino esters with 99% purity can be prepared in a practically large scale (60 g) without using silica gel column chromatography. The utility of the present method was fortified by the preparation of pharmaceutically useful indeno-4-hydroxypyridin-2(1H)-one analogue 11.
