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2,2-bis(hydroxymethyl)-1-azabicyclo[2.2.2]octan-3-ol, commonly known as tris(hydroxymethyl)aminomethane or Tris, is a fundamental chemical compound widely utilized in the fields of biochemistry and molecular biology. This white, crystalline solid is highly soluble in water and is recognized for its capacity to maintain a stable pH in a variety of biological and chemical processes. Its versatility and properties make it a valuable component in numerous applications.

5291-31-6

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5291-31-6 Usage

Uses

Used in Biochemistry and Molecular Biology:
2,2-bis(hydroxymethyl)-1-azabicyclo[2.2.2]octan-3-ol is used as a buffering agent for maintaining a stable pH in biological and biochemical experiments. Its ability to resist drastic pH changes is crucial for the accurate and reliable results of these experiments.
Used in Pharmaceutical Formulation:
In the pharmaceutical industry, 2,2-bis(hydroxymethyl)-1-azabicyclo[2.2.2]octan-3-ol is used as a component in the formulation of various drugs. Its buffering capacity helps to stabilize the pH of medications, ensuring their efficacy and safety.
Used in Personal Care Products:
2,2-bis(hydroxymethyl)-1-azabicyclo[2.2.2]octan-3-ol is utilized as a stabilizer and emulsifier in the production of personal care products. Its properties help to maintain the consistency and effectiveness of these products, contributing to their quality and performance.
Used in Food and Beverage Industry:
In the food and beverage sector, 2,2-bis(hydroxymethyl)-1-azabicyclo[2.2.2]octan-3-ol is used as a stabilizer and emulsifier. It helps to improve the texture, taste, and shelf life of various food and drink products.
Used in Synthesis of Certain Drugs:
2,2-bis(hydroxymethyl)-1-azabicyclo[2.2.2]octan-3-ol is employed in the synthesis of certain pharmaceutical compounds. Its chemical properties make it a useful intermediate in the production of specific medications.
Used in Electrophoresis Gels for DNA and Protein Analysis:
In the field of molecular biology, 2,2-bis(hydroxymethyl)-1-azabicyclo[2.2.2]octan-3-ol is used as a component in the preparation of electrophoresis gels. These gels are essential for the separation and analysis of DNA and proteins, facilitating research and diagnostics.
It is important to handle 2,2-bis(hydroxymethyl)-1-azabicyclo[2.2.2]octan-3-ol with care due to its potential hazards. It can cause irritation to the skin, eyes, and respiratory system if not properly managed.

Check Digit Verification of cas no

The CAS Registry Mumber 5291-31-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,2,9 and 1 respectively; the second part has 2 digits, 3 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 5291-31:
(6*5)+(5*2)+(4*9)+(3*1)+(2*3)+(1*1)=86
86 % 10 = 6
So 5291-31-6 is a valid CAS Registry Number.

5291-31-6Downstream Products

5291-31-6Relevant academic research and scientific papers

Structure-activity studies of quinuclidinone analogs as anti-proliferative agents in lung cancer cell lines

Malki, Ahmed,Pulipaka, Aravinda B.,Evans, Susan C.,Bergmeier, Stephen C.

, p. 1156 - 1159 (2006)

We have synthesized and tested novel quinuclidinone analogs to assay the effects on H1299 lung cancer cell lines alone or with γ-radiation. We have found two series of quinuclidinone analogs that act as anti-cancer agents. Of these, four interesting analo

QUINUCLIDINONE DERIVATIVES AS ANTICANCER AGENTS

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Page/Page column 7, (2008/06/13)

New compounds of formula (I): wherein R1 and R2 may be the same or different and are selected from H, halo, alkyl, cycloalkyl, haloalkyl, aryl, haloaryl, alkylaryl, alkoxyaryl, hydroxyl, acetate, ketal, alkoxy, and combinations there

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