52918-92-0 Usage
Uses
Used in Pharmaceutical Industry:
CHENODEOXYCHOLIC ACID-24-13C is used as a research tool for studying the metabolism and transport of bile acids in the body. The presence of the carbon-13 isotope allows for the tracking and analysis of the compound's behavior in various biological processes.
Used in Diagnostic Applications:
In the medical field, CHENODEOXYCHOLIC ACID-24-13C can be employed as a diagnostic agent to investigate bile acid metabolism disorders and related conditions, such as cholestasis and gallstones. The isotope labeling enables the detection and monitoring of the compound's distribution and excretion patterns.
Used in Drug Development:
CHENODEOXYCHOLIC ACID-24-13C can be utilized in the development of new drugs targeting bile acid metabolism and related pathways. The isotope-labeled compound can help researchers understand the mechanisms of action and potential side effects of these drugs, leading to the design of more effective and safer therapeutic agents.
Used in Nutritional Research:
In the field of nutrition, CHENODEOXYCHOLIC ACID-24-13C can be used to study the role of bile acids in the absorption and metabolism of dietary fats and lipids. This information can contribute to the development of dietary interventions and supplements aimed at improving lipid metabolism and overall health.
Check Digit Verification of cas no
The CAS Registry Mumber 52918-92-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,2,9,1 and 8 respectively; the second part has 2 digits, 9 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 52918-92:
(7*5)+(6*2)+(5*9)+(4*1)+(3*8)+(2*9)+(1*2)=140
140 % 10 = 0
So 52918-92-0 is a valid CAS Registry Number.
52918-92-0Relevant articles and documents
An improved synthesis of 24 13C labeled bile acids using formyl esters and a modified lead tetraacetate procedure
Tserng,Klein
, p. 400 - 403 (2007/10/13)
An improved synthesis of 24 14C labeled bile acids has been achieved using formyl derivatives of bile acids and a modified lead tetraacetate procedure. The formylated bile acids were degraded by lead tetraacetate and lithium chloride to formylated 23 chloronorcholanes in 72 to 83% yield. Formylated 23-chloronorcholanes were converted to nitriles in dimethylformamide, which were then hydrolyzed to obtain C-24 labeled bile acids in yield of 80 to 90% of labeled sodium cyanide used. This method results in a higher yield and a purer product with less manipulation than previously reported procedures for synthesis of labeled bile acids.
Syntheses with stable isotopes: synthesis of deuterium and 13C labeled bile acids
Hachey,Szczepanik,Berngruber,Klein
, p. 703 - 719 (2007/10/16)
A series of 5β cholanic acids labeled with deuterium in the A ring were prepared by exchange labeling of the corresponding ketone by column chromatography on deuterated alumina. Factors affecting yield and labeling efficiency are discussed. 5β Cholanic acids labeled with 13C in the carboxyl position were prepared by treatment of the corresponding 23 chloro 24 norcholane with sodium cyanide 13C followed by alkaline hydrolysis of the nitrile. The intermediates in the synthesis were characterized by high resolution NMR spectroscopy. Mass spectra are also reported for the 13C labeled products.
