52936-89-7

Upstream product

• 186581-53-3 diazomethane 
• 13850-16-3 euscaphic acid 

Relevant academic research and scientific papers

Triterpenes from Paliurus hemsleyanus

Separation of the water-insoluble fraction of the ethanol extract from the root of Paliurus hemsleyanus led to the isolation of three new triterpenes. They are ceanothic acid derivatives named zizyberenalic acid ceanothanolic acid and 2-O-(p-coumaroyl)-ceanothanolic acid. Additional NMR data for the known colubrinic acid and euscaphic acid, the latter being characterized as methyl ester, were also assigned.

Tormentic acid derivatives: Synthesis and apoptotic activity

Several derivatives of tormentic acid have been prepared and tested for their antitumor activity. The dichloroacetate 14 is an excellent antitumor active agent acting by an apoptose inducing pathway as demonstrated by OA/PI staining, DNA laddering experiments as well as by an annexin V binding assay.

Triterpenoids and other compounds from Salvia roborowskii Maxim

Two new triterpenoids, 2α-hydroxy-3β-methoxyurs-12-en-28-oic acid and 3α-hydroxy-2α-methoxyurs-12-en-28-oic acid as well as 25 known compounds were isolated from the whole plant of Salvia roborowskii Maxim. Their structures were elucidated by means of spectral data and chemical transformation. This is the first report on the chemical constituents of this plant. The presence of eugenyl β-D-glucopyranoside 22 in a plant of the genus Salvia is also reported for the first time.

Triterpene phytoalexins from strawberry fruit.

Strawberry cv. Houkouwase is resistant to infection by Colletotrichum fragariae. The formation of antifungal compounds was observed in unripe fruit which had been wounded and inoculated with conidia of C. musae. Three antifungal compounds were isolated and identified as euscaphic acid, tormentic acid and myrianthic acid. Myrianthic acid inhibited the growth of C. musae at 3 microg, and euscaphic and tormentic acids showed inhibitory effects at 100 microg. A quantitative analysis of their contents showed that the triterpenes increased in wounded fruit, and in wounded and inoculated fruit, but not in non-treated fruit. These findings indicate that unripe fruit of Houkouwase produced the triterpenes as phytoalexins. The triterpene phytoalexins seem to be involved in the resistance of strawberry to the fungus.

Chemical Constituents from the Root and Aerial Parts of Rosa taiwanensis

The root and aerial parts of Rosa taiwanensis Nakai contain the chemical constituents phenols, unsaturated acids, liolide, abscisic acid, flavones, sterols, lupeol, betulin, betulinic acid, oleanolic acid and ursolic acid derivatives.Among them, 2α,3α-dihydroxyurs-12,19-dien-28-oic acid and its C-3 epimer are new compounds.Key Words Rosa taiwanensis; Rosaceae; Aerial part; Root; Flavones; Ursolic acid derivatives; Lupeol; Betulin; Oleanolic acid.