5294-53-1Relevant academic research and scientific papers
Homogeneous and stereoselective copper(II)-catalyzed monohydration of methylenemalononitriles to 2-cyanoacrylamides
Xin, Xiaoqing,Xiang, Dexuan,Yang, Jiming,Zhang, Qian,Zhou, Fenguo,Dong, Dewen
, p. 11956 - 11961 (2014/01/06)
A facile and efficient route for the homogeneous and highly stereoselective monohydration of substituted methylenemalononitriles to (E)-2-cyanoacrylamides catalyzed by copper(II) acetate monohydrate in acetic acid containing 2% water is described, and a mechanism is proposed. The protocol has proved to be suitable for the monohydration of dicyanobenzenes and 2-substituted malononitriles.
Titanium isopropoxide/pyridine mediated Knoevenagel reactions
Robichaud, Brian A.,Liu, Kevin G.
experimental part, p. 6935 - 6938 (2012/02/05)
We report a Ti(OiPr)4/pyridine-mediated Knoevenagel reaction between aromatic ketones and cyanoacetamides to provide Knoevenagel olefin products in good to excellent yields. Almost in all cases studied, a single geometrical isomer was formed an
Thiophene derivatives
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, (2008/06/13)
Compounds of the formula: SPC1 Wherein R1 is NHR5 or OR5 where R5 is a hydrogen atom or alkyl group of 1-6 carbon atoms; R2 is a hydrogen atom or a CO.R6 group where R6 is an alk
