52940-41-7

Upstream product

• 89211-43-8 2-Brom-2-nitro-pentylamin 
• 19265-24-8 1-chloropentane-2-one 
• 29505-09-7 1-diethylamino-2-pentanone 
• 91761-98-7 N-(2-bromo-2-nitro-pentyl)-phthalimide 
• 5699-69-4 amino-2 pentanenitrile 

Relevant academic research and scientific papers

ORGANIC COMPOUNDS

The present invention provides heterocyclicderivatives that modulate the activity of stearoyl-CoA desaturase. Methods of using such derivatives to modulate the activity of stearoyl-CoA desaturase and pharmaceutical compositions comprising such derivatives are also encompassed.

HETEROCYCLIC DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS

Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): where x, y, G, J, K, L, M, V R2, R3, R4, R5, R5a, R6, R6a, R7, R7a, R8 and R8a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.