52940-98-4

Basic information

• Product Name: 5'-Adenylic acid, N-acetyl-7,8-dihydro-8-oxo-, 3'-acetate 2'-(4-methylbenzenesulfonate)
• CAS NO: 52940-98-4
• Molecular Formula: C21H24N5O12PS
• Molecular Weight: 601.488
• Mol File: 52940-98-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5'-Adenylic acid, N-acetyl-7,8-dihydro-8-oxo-, 3'-acetate 2'-(4-methylbenzenesulfonate)(CAS DataBase Reference)
• NIST Chemistry Reference: 5'-Adenylic acid, N-acetyl-7,8-dihydro-8-oxo-, 3'-acetate 2'-(4-methylbenzenesulfonate)(52940-98-4)
• EPA Substance Registry System: 5'-Adenylic acid, N-acetyl-7,8-dihydro-8-oxo-, 3'-acetate 2'-(4-methylbenzenesulfonate)(52940-98-4)

Safety Data

• Hazardous Substances Data: 52940-98-4(Hazardous Substances Data)

Upstream product

• 28220-13-5 8-bromo-O^2'-(toluene-4-sulfonyl)-[5']adenylic acid 
• 108-24-7 acetic anhydride 

Downstream Products

• 29984-33-6 vidarabine monophosphate 
• 65030-14-0 phosphoric acid mono-((6aS)-4-benzoylamino-7c-benzoyloxy-(6ar,9ac)-6a,7,8,9a-tetrahydro-furo[2',3':4,5]oxazolo[3,2-e]purin-8t-ylmethyl) ester 

Relevant articles and documents

Synthetic method of vidarabine monophosphate

The invention provides a synthetic method of vidarabine monophosphate. The synthetic method comprises the following steps: a) making an intermediate shown as a formula (II) react with a solid sulfurizing agent and strong-acid ion exchange resin to obtain an intermediate shown as a formula (III), wherein the solid sulfurizing agent is selected from sodium sulfide, a sodium sulfide hydrate, sodium hydrosulfide or a sodium hydrosulfide hydrate; b), desulfurizing the intermediate shown as the formula (III) to obtain the vidarabine monophosphate. In the method, the intermediate shown as the formula (II) is subjected to sulfhydrylation through the solid sulfurizing agent such as the sodium sulfide, the sodium bisulfide, the sodium sulfide hydrate or the sodium hydrosulfide hydrate and the strong-acid ion exchange resin, and is desulfurized to obtain the vidarabine monophosphate, so that the use of hydrogen sulfide is avoided, and the pressure on the environment is lowered. Meanwhile, by adopting the synthetic method provided by the invention, the yield is 30 percent or more, and the purity of an obtained product is 99.8 percent or more.