529474-48-4

Upstream product

• 529474-45-1 (5S,8S)-2-(2-Benzenesulfonyl-ethyl)-1,3-dioxo-8-((2S,3R,4S,5R,6R)-3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxy)-2,3,5,8-tetrahydro-1H-[1,2,4]triazolo[1,2-a]pyridazine-5-carboxylic acid benzyl ester 
• 15097-38-8 (carbobenzyloxymethylene)triphenylphosphorane 
• 152094-22-9 Benzyl (2E,4E)-5-(2`,3`,4`,6`-tetra-O-acetyl-β-D-glucopyranoyloxy)penta-2,4-dienoate 

Downstream Products

• 529474-50-8 2-(2-benzenesulfonyl-ethyl)-1,3-dioxo-hexahydro-[1,2,4]triazolo[1,2-a]pyridazine-5-carboxylic acid 

Relevant academic research and scientific papers

Asymmetric synthesis and conformational analysis of the two enantiomers of the saturated analog of the potent thrombin inhibitor MOL-376

Asymmetric synthesis of the two enantiomers of a small molecule thrombin inhibitor is described. The key step in the synthesis is the glucose-directed chiral induction in the hetero Diels-Alder cycloaddition step. Conformational analysis indicates that th