529484-00-2Relevant academic research and scientific papers
Asymmetric synthesis of potent glycosidase and very potent α-mannosidase inhibitors: 4-amino-4-deoxy-L-erythrose and 4-amino-4,5-dideoxy-L-ribose
Behr, Jean-Bernard,Chevrier, Carine,Defoin, Albert,Tarnus, C.éline,Streith, Jacques
, p. 543 - 553 (2007/10/03)
Pyrrolidine amino-sugars, cyclic iminoalditols as well as linear aminoalditols in 4-amino-L-erythrose and 4-amino-5-deoxy-L-ribose series were synthesised by asymmetric hetero-Diels-Alder reaction followed by chemical transformations. 4-Amino-4-deoxy-L-erythrose and 4-amino-4,5-dideoxy-L-ribose were potent β-D-glucosidase, α-D-mannosidase, α- and β-D-galactosidase inhibitors. We have shown that the ribose derivative was a very potent inhibitor of α-D-mannosidase.
