5296-17-3

Usage

Chemical class

Piperidine derivatives

Physical state

White solid

Molecular weight

231.32 g/mol

Pharmaceutical applications

Building block in the synthesis of drugs such as sedatives, analgesics, and antihistamines

Potential properties

Antifungal and antibacterial

Industrial uses

Organic synthesis, chemical intermediate in the production of other compounds.

Upstream product

• 110-89-4 piperidine 
• 2186-24-5 cresyl-glicidyl ether 

Relevant academic research and scientific papers

Process for the solid state synthesis of enantiopure B-aminoalcohols from racemic epoxides

The invention relates to a process for the solid state synthesis of enantiopure β-aminoalcohols by preparing inclusion complexes of aryloxyepoxide with cyclodextrin by adding an epoxide in equimolar ratio in an organic solvent to an aqueous solution of cyclodextrin, reacting the cyclodextrin complex of aryloxyepoxide with a nucleophile in solid state by intimately grinding the mixture using a mortar and pestle, continuing the mixing till the starting epoxide disappeared on tic, removing excess amines under vacuum, extracting the β-aminoalcohols produced with a solvent with yields of more than 50% and enantioselectivity of upto 100%.