5296-90-2

Usage

Chemical structure

1-phenylcyclopentane-1-amine hydrochloride is a hydrochloride salt of 1-phenylcyclopentane-1-amine, which consists of a cyclopentane ring with a phenyl group attached to it, and an amine group (-NH2) attached to the first carbon of the cyclopentane ring.

Type of compound

It is an amine compound, specifically a hydrochloride salt of an amine.

Pharmaceutical use

1-phenylcyclopentane-1-amine hydrochloride is commonly used as a pharmaceutical intermediate in the synthesis of various pharmaceutical drugs, particularly those targeting the central nervous system.

Application in drug synthesis

It is used in the manufacturing of certain neurotransmitter modulators and neuroprotective agents.

Stability and solubility

The hydrochloride salt form of 1-phenylcyclopentane-1-amine is more stable and has a higher solubility in water, making it more suitable for use in pharmaceutical applications.

Significance in the pharmaceutical industry

This chemical compound plays a significant role in the production of various drugs and medications, particularly those related to the central nervous system.

Upstream product

• 100-47-0 benzonitrile 
• 23708-47-6 1,4-bis(bromomagnesium)butane 
• 5296-89-9 1-phenylcyclopentane-1-carboxamide 

Relevant academic research and scientific papers

Oxadiazole Amine Derivative Compounds as Histone Deacetylase 6 Inhibitor, and the Pharmaceutical Composition Comprising the same

The present invention relates to a novel compound having an activity of inhibiting histone deacetylase 6 (HDAC6), an optical isomer thereof or a pharmaceutically acceptable salt thereof, a use thereof for preparation of a drug for treatment, a pharmaceutical composition comprising the same, a treatment method using the composition, and a method for preparing the same. The novel compound, an optical isomer thereof or a pharmaceutically acceptable salt thereof according to the present invention has an activity of inhibiting histone deacetylase 6 (HDAC6), and is effective for preventing or treating HDAC6-related diseases, including infectious diseases; neoplasm; endocrine, nutritional and metabolic diseases; mental and behavior disorders; nerve disorders; eye and adnexa diseases; cardiovascular diseases; respiratory diseases; digestive organ diseases; skin and subcutaneous tissue diseases; musculoskeletal and connective tissue diseases; or congenital malformation, deformation and chromosomal abnormality.COPYRIGHT KIPO 2017

1-Substituted cyclopentylamines from nitriles and tetramethylenebismagnesium dibromide in the presence of Ti(OiPr)4

Various 1-substituted cyclopentylamines (25 examples, 1089 % yield) have been prepared according to a one-pot procedure by the addition of tetramethylenebismagnesium. di- bromide in the presence of Ti(OiPr)4 to aliphatic, aromatic and heteroaromatic nitriles, respectively.