52962-41-1Relevant academic research and scientific papers
Development of water-soluble far-red fluorogenic dyes for enzyme sensing
Ho, Nan-Hui,Weissleder, Ralph,Tung, Ching-Hsuan
, p. 578 - 585 (2006)
A series of Nile Blue analogs, 5-amino-9-dialkylamino benzo[a]phenoxazine dyes, 7-9, were prepared by condensation of N-alkyl or N-sulfo-propyl 4-arylazo-substituted 3-hydroxyaniline with 4-arylazo-substituted 1-naphthlamines or 8-amino-2-naphthalenesulfo
A Water-Soluble, Green-Light Triggered, and Photo-Calibrated Nitric Oxide Donor for Biological Applications
He, Haihong,Xia, Yang,Qi, Yingxue,Wang, Hong-Yin,Wang, Zhuang,Bao, Jianming,Zhang, Ziqian,Wu, Fu-Gen,Wang, Haolu,Chen, Daijie,Yang, Dahai,Liang, Xiaowen,Chen, Jinquan,Zhou, Shengmin,Liang, Xin,Qian, Xuhong,Yang, Youjun
, p. 1194 - 1198 (2018)
Nitric oxide (NO) is a versatile endogenous molecule, involved in various physiological processes and implicated in the progression of many pathological conditions. Therefore, NO donors are valuable tools in NO related basic and applied applications. The traditional spontaneous NO donors are limited in scenarios where flux, localization, and dose of NO could be monitored. This has promoted the development of novel NO donors, whose NO release is not only under control, but also self-calibrated. Herein, we reported a phototriggered and photocalibrated NO donor (NOD565) with an N-nitroso group on a rhodamine dye. NOD565 is nonfluorescent and could release NO efficiently upon irradiation by green light. A bright rhodamine dye is generated as a side-product and its fluorescence can be used to monitor the NO release. The potentials of NOD565 in practical applications are showcased in in vitro studies, e.g., platelet aggregation inhibition and fungi growth suppression.
Structural modifications of nile red carbon monoxide fluorescent probe: Sensing mechanism and applications
Klán, Petr,Madea, Dominik,Martínek, Marek,Muchová, Lucie,Váňa, Ji?í,Vítek, Libor
, p. 3473 - 3489 (2020/03/25)
Carbon monoxide (CO) is a cell-signaling molecule (gasotransmitter) produced endogenously by oxidative catabolism of heme, and the understanding of its spatial and temporal sensing at the cellular level is still an open challenge. Synthesis, optical properties, and study of the sensing mechanism of Nile red Pd-based CO chemosensors, structurally modified by core and bridge substituents, in methanol and aqueous solutions are reported in this work. The sensing fluorescence "off-on" response of palladacycle-based sensors possessing low-background fluorescence arises from their reaction with CO to release the corresponding highly fluorescent Nile red derivatives in the final step. Our mechanistic study showed that electron-withdrawing and electron-donating core substituents affect the rate-determining step of the reaction. More importantly, the substituents were found to have a substantial effect on the Nile red sensor fluorescence quantum yields, hereby defining the sensing detection limit. The highest overall fluorescence and sensing rate enhancements were found for a 2-hydroxy palladacycle derivative, which was used in subsequent biological studies on mouse hepatoma cells as it easily crosses the cell membrane and qualitatively traces the localization of CO within the intracellular compartment with the linear quantitative response to increasing CO concentrations.
Dye compounds
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Page/Page column 32; 34, (2019/11/26)
The present invention relates to dye compounds represented by Formulae I and II, which are described in the specification. The dye compounds of the present invention have markedly improved quantum yields and emit strong fluorescence compared to existing cyanine dyes. Due to these advantages, the dye compounds of the present invention can find applications in various fields, for example, as probes for various biological systems where optical imaging is required. Particularly, the dye compounds of the present invention can be used as mitotrackers capable of labeling and tracking mitochondria. Therefore, the dye compounds of the present invention can be used to quantitatively image mitochondria in live tissues and cells. Furthermore, the dye compounds of the present invention can be applied as pH probes for measuring the pH of live cells.
FLUOROGENIC pH-SENSITIVE DYES, FILM AND KIT COMPRISING THE SAME
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Paragraph 0223; 0236-0240, (2018/10/03)
The present invention refers to a sulfonyl (- S02 ) With aryl compounds; and said aryl sulfonyl compound to (- S02 ) For detecting dye compound including pH agarose (agarose) shared coupled compounds are disclosed. (by machine translation)
Nitric oxide donors, preparation and applications of nitric oxide donors
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Paragraph 0166-0168, (2018/03/24)
The invention relates to nitric oxide donors, preparation and applications of the nitric oxide donors. In particular, the invention provides compounds which have structures represented by a formula I, wherein R2 is H, a C3-C8 naphthenic group or C1-C6 alkyl which is substituted by 1-2 materials optionally selected from C1-C4 alkoxy, -S(O)2-OH, and a substituent group of hydroxyl, and N is connected with a benzene ring of a fluorophore molecule. The invention also provides preparation methods for the compounds represented by the formula I, compositions containing the compounds represented in the formula I, and the applications of the compounds which are used as the nitric oxide donors.
