52964-29-1Relevant academic research and scientific papers
COMPOUNDS FOR INHIBITION OF ALPHA 4 BETA 7 INTEGRIN
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Paragraph 0435, (2020/05/28)
The present disclosure provides a compound of Formula (I): or a pharmaceutically acceptable salt thereof as described herein. The present disclosure also provides pharmaceutical compositions comprising a compound of Formula (I), processes for preparing compounds of Formula (I), and therapeutic methods for treating inflammatory disease.
Amplifying fluorescent conjugated polymer sensor for singlet oxygen detection
Wang, Chun-Han,Nesterov, Evgueni E.
, p. 8955 - 8958 (2019/07/31)
A "higher energy gap" concept was applied towards designing an efficient turn-on amplifying sensor for singlet oxygen-an important biomedical and environmental monitoring analytical target. The concept is based on modulation of intramolecular energy trans
A novel amino-benzosuberone derivative is a picomolar inhibitor of mammalian aminopeptidase N/CD13
Maiereanu, Carmen,Schmitt, Céline,Schifano-Faux, Nadge,Le Nou?n, Didier,Defoin, Albert,Tarnus, Céline
, p. 5716 - 5733 (2011/10/12)
A new class of low molecular weight, highly potent and selective non peptidic inhibitors of aminopeptidase N (APN/CD13) is described. We report the synthesis and in vitro evaluation of racemic substituted analogues of 7-amino-benzocyclohepten-6-one 1a. We
DIINDENOPICENE COMPOUND AND ORGANIC LIGHT EMITTING DEVICE USING THE SAME
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Page/Page column 35-37, (2011/04/25)
The present invention provides an organic light emitting device which shows a blue light emission hue of remarkably good color purity and has a high-efficiency and high-luminance optical output. An organic light emitting device including an anode 2, a cat
Lanthanide-Catalyst-Mediated Tandem Double Intramolecular Hydroalkoxylation/Cyclization of Dialkynyl Dialcohols: Scope and Mechanism
Seo, Sungyong,Marks, Tobin J.
scheme or table, p. 5148 - 5162 (2010/08/05)
Lanthanide-organic complexes of the general type [Ln{N-(SiMe 3)2}3] (Ln = La, Sm, Y, Lu) serve as effective precatalysts for the rapid, exo-selective, and highly regioselective tandem double intramolecular hydroalkoxylation/cyclization of primary and secondary dialkynyl dialcohols to yield the corresponding bi-exocyclic enol ethers. Conversions are highly selective with products distinctly different from those generally produced by conventional transition metal or other catalysts, and the turnover frequencies with some substrates are too large to determine accurately. The rates of terminal alkynl alcohol hydroalkoxylation/cyclization are significantly more rapid than those of internal alkynyl alcohols, arguing that steric demands dominate the cyclization transition state. The hydroalkoxylation/cyclizations of internal dialkynyl dialcohols afford excellent E selectivity. The rate law for dialkynyl dialcohol hydroalkoxylation/ cyclization is first-order in [catalyst] and zero-order in [alkynyl alcohol], as is observed for the organolanthanide-catalyzed hydroamination/cyclization of aminoalkenes, aminoalkynes, and aminoallenes, and the intramolecular single-step hydroalkoxylation/cyclization of alkynyl alcohols. An ROH/ROD kinetic isotope effect of 0.82(0.02) is observed for the tandem double hydroalkoxylation/ cyclization. These mechanistic data implicate turnover-limiting insertion of C-C unsaturation into the Ln-O bond, involving a highly organized transition state, with subsequent, rapid Ln-C protonolysis.
Methylene-bridged glycoluril dimers: Synthetic methods
Wu, Anxin,Chakraborty, Arindam,Witt, Dariusz,Lagona, Jason,Damkaci, Fehmi,Ofori, Marie A.,Chiles, Jessica K.,Fettinger, James C.,Isaacs, Lyle
, p. 5817 - 5830 (2007/10/03)
Methylene-bridged glycoluril dimers are the fundamental building blocks of cucurbituril (CB[6]), its homologues (CB[n]), and its derivatives. This paper describes three complementary methods for the synthesis of C- and S-shaped methylene-bridged glycoluril dimers (29-34 and 37-44). For this purpose, we prepared glycoluril derivatives (1a-d) bearing diverse functionalities on their convex face. These glycoluril derivatives were alkylated under basic conditions (DMSO, t-BuOK) with 1,2-bis(halomethyl)aromatics 6-15 to yield 4a-d and 16-24, which contain a single aromatic o-xylylene ring and potentially nucleophilic ureidyl NH groups. Glycoluril derivatives bearing potentially electrophilic cyclic ether groups (5a-f) and 25-28 were prepared by various methods including condensation reactions in refluxing TFA containing paraformaldehyde. The condensation reactions of 4a-d and 16-24 with paraformaldehyde under anhydrous acidic conditions (PTSA, ClCH2CH2Cl, reflux) give, in most cases, the C-shaped and S-shaped methylene-bridged glycoluril in good to excellent yields. In many cases, the C-shaped compound is formed preferentially with high diastereoselectivity. Cyclic ethers 5a,d-f and 25-26 undergo highly diastereoselective dimerization reactions to yield methylene-bridged glycoluril dimers with the formal extrusion of formaldehyde. Last, it is possible to perform selective heterodimerization reactions using both cyclic ethers and glycoluril derivatives bearing ureidyl NH groups. These reactions deliver the desired C- and S-shaped heterodimers with low to moderate diastereoselectivities. This heterodimerization route is the method of choice in cases where the homodimerization reactions fail. The formation of side products (±)-35b and (±)-35d helps clarify the electronic requirements for a successful CB[n] synthesis. The x-ray structures of 30C, 38C, and 38S allow for a discussion of the structural features of this class of compounds.
