52982-90-8

Usage

Chemical compound

2-Amino-6-chloro-4-methyl-nicotinonitrile

Class

Nitriles

Functional groups

Amino group, chloro group, methyl group

Appearance

White to light yellow crystalline powder

Uses

Intermediate in the synthesis of pharmaceuticals, pesticides, and other organic compounds; production of agrochemicals; building block in the preparation of heterocyclic compounds

Potential applications

Research and development of new drugs

Caution

Properties, hazards, and safety measures should be carefully evaluated before use

InChI:InChI=1/C7H6ClN3/c1-4-2-6(8)11-7(10)5(4)3-9/h2H,1H3,(H2,10,11)

Upstream product

• 875-35-4 2,6-dichloro-4-methylnicotinonitrile 
• 5444-02-0 2,6-dihydroxy-3-cyano-4-methylpyrimidine 

Relevant academic research and scientific papers

NEW TRPA1 ANTAGONISTS

The present invention relates to bicyclic heterocyclic derivatives of Forrmula (I), to the process for preparing such compounds and to their use in the treatment of a pathological condition or disease susceptible to amelioration by TRPA1 channel inhibition or antagonism.

NEW TRPA1 ANTAGONISTS

The present invention relates to compounds of Formula (I), to the process for preparing such compounds and to their use in the treatment of a pathological condition or disease susceptible to amelioration by TRPA1 channel inhibition or antagonism.

Synthesis and Reactivity of 2,6-Diamino-4-methyl-3-pyridinecarbonitrile

2,6-Dihydroxy-4-methyl-3-pyridinecarbonitrile is converted via its 2,6-dichloro analog into the corresponding 2-amino-6-chloro, 2-chloro-6-amino, and 2,6-diamino derivatives.The last reacts with benzenesulfonyl chloride to yield a tris-sulfonyl derivative, the structure of which is demonstrated by X-ray analysis.