52987-17-4Relevant academic research and scientific papers
Palladium-catalyzed Heck-type reaction of oximes with allylic alcohols: Synthesis of pyridines and azafluorenones
Zheng, Meifang,Chen, Pengquan,Wu, Wanqing,Jiang, Huanfeng
supporting information, p. 84 - 87 (2015/12/26)
We describe herein a palladium-catalyzed Heck-type reaction of O-acetyl ketoximes and allylic alcohols to synthesise pyridines. This protocol allows the robust synthesis of pyridines and azafluorenones in good to excellent yields with tolerance of various functional groups under mild conditions. The reaction is supposed to go through an oxidative addition of oximes to palladium(0) complexes, generating an alkylideneamino-palladium(ii) species, which is utilized as a key intermediate to capture the nonbiased alkenes for carbon-carbon bond formation.
Process for the production of substituted pyridine (B)
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, (2008/06/13)
Pyridines substituted in the 2- and 3-positions by aromatic or heteroaromatic groups are prepared by reacting an aromatic or heteroaromatic substituted ketone which has at least one reactive methylene group adjacent to the keto group with an aliphatic oxo compound having a carbon to carbon ethylenic double bond on the carbon atom adjacent to the oxo group and ammonia in the presence of a dehydrating and dehydrogenating catalyst at a temperature of about 250° to 550° C.
