52988-34-8

Basic information

• Product Name: 4'-Methoxybiphenyl-4-carbaldehyde
• Synonyms: [1,1'-BIPHENYL]-4-CARBOXALDEHYDE, 4'-METHOXY-;AKOS BAR-0060;4'-METHOXY-BIPHENYL-4-CARBALDEHYDE;4'-METHOXY-BIPHENYL-4-CARBOXALDEHYDE;4'-METHOXY[1,1'-BIPHENYL]-4-CARBOXALDEHYDE;4'-METHOXY[1,1'-BIPHENYL]-4-CARBALDEHYDE;4-(4-METHOXYPHENYL)BENZALDEHYDE;4-(4-METHOXY)BENZALDEHYDE
• CAS NO: 52988-34-8
• Molecular Formula: C₁₄H₁₂O₂
• Molecular Weight: 212.24
• Mol File: 52988-34-8.mol
• Article Data: 4

Chemical Properties

• Melting Point: 98-100°C
• Boiling Point: 363.5 °C at 760 mmHg
• Flash Point: >110°(230°F)
• Appearance: /
• Density: 1.114 g/cm³
• Storage Temp.: Inert atmosphere,Room Temperature
• Sensitive: Air Sensitive
• CAS DataBase Reference: 4'-Methoxybiphenyl-4-carbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-Methoxybiphenyl-4-carbaldehyde(52988-34-8)
• EPA Substance Registry System: 4'-Methoxybiphenyl-4-carbaldehyde(52988-34-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 52988-34-8(Hazardous Substances Data)

Usage

Uses

4''-Methoxybiphenyl-4-carboxaldehyde acts as a reagent in the research studies involving the use of aryliden-methyloxazolones as reversible MAGL inhibitors for cancer treatment.

Upstream product

• 127591-24-6 p-methoxyphenyl(triphenylphosphine)gold(I) 
• 1122-91-4 4-bromo-benzaldehyde 
• 1130440-65-1 [4-(trifluoromethyl)phenyl](triphenylphosphine)gold(I) 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 29304-87-8 7-(4-methoxyphenyl)cyclohepta-1,3,5-triene 
• 87199-17-5 4-formylphenylboronic acid, 
• 1018955-96-8 6-(4-methoxyphenyl)bicyclo[3.2.0]hept-2-en-6-ol 

Downstream Products

• 75472-33-2 N,N-bis(p-methoxyphenylbenzylidene)-α,α'-bi-p-toluidine 
• 162755-27-3 (E)-2-<4-(4-methoxyphenyl)benzylidene>-p-menthan-3-one 
• 477726-56-0 3-(2-Amino-6-methyl-pyrimidin-4-yl)-biphenyl-4,4'-diol 
• 613-37-6 4-methoxylbiphenyl 
• 1380049-03-5 (S)-2-{(R)-hydroxy[4'-methoxy-1,1'-biphenyl-4-yl]methyl}cyclopentanone 

Relevant articles and documents

Gold Catalysts Can Generate Nitrone Intermediates from a Nitrosoarene/Alkene Mixture, Enabling Two Distinct Catalytic Reactions: A Nitroso-Activated Cycloheptatriene/Benzylidene Rearrangement

Gold-catalyzed reactions of cycloheptatrienes with nitrosoarenes yield nitrone derivatives efficiently. This reaction sequence enables us to develop gold-catalyzed aerobic oxidations of cycloheptatrienes to afford benzaldehyde derivatives using CuCl and nitrosoarenes as co-catalysts (10-30 mol %). Our density functional theory calculations support a novel nitroso-activated rearrangement, tropylium → benzylidene. With the same nitrosoarenes, we developed their gold-catalyzed [2 + 2 + 1]-annulations between nitrosobenzene and two enol ethers to yield 5-alkoxyisoxazolidines using 1,4-cyclohexadienes as hydrogen donors.

Nickel-catalyzed cross-coupling of organogold reagents

Organogold compounds undergo nickel-catalyzed cross-coupling reactions with aryl and vinyl bromides in high yield under mild conditions. The reaction tolerates both electron-rich and electron-poor organogold complexes, and olefinic bromides undergo cross-coupling with high stereoselectivity. This novel transformation links well-established nickel catalysis with more recent developments in organogold transformations.