53-33-8Relevant articles and documents
Preparation method of palamethasone acetate and palamethasone
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Paragraph 0035; 0061-0064, (2022/03/27)
The invention provides a palamethasone acetate and a preparation method of palamethasone, 16-methyl hydroxyl epoxy progesterone is used as an initial raw material, fluorination, bromination, debromination, iodination and replacement reaction are sequentially performed to obtain the palamethasone acetate, and then the palamethasone acetate is hydrolyzed to obtain the palamethasone. The preparation process route provided by the invention has fewer reaction steps, the quality and yield of the product have obvious competitiveness, dangerous chemical processes are not involved, the method is green and clean, and the atom economy is improved; the preparation process has a wide industrial application prospect.
Mucosal adhesive device for long-acting delivery of pharmaceutical combinations in oral cavity
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, (2008/06/13)
Mucosal adhesive devices are provided for use in the oral cavity for therapy against infections. The devices are dosage units which comprise a combination of antimicrobial agents such as antifungal agents and anti-inflammatory agents, optionally also a local anesthetic. The dosage units yield a gradual and relatively constant release of the pharmaceuticals over at least a 12-hour period.
Amine containing ester prodrugs of corticosteroids
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, (2008/06/13)
Novel solution stable ester prodrugs of corticosteroids of the formula STR1