53-40-7 Usage
General Description
The chemical compound (2beta,3alpha,5alpha)-3-hydroxy-2-(morpholin-4-yl)pregnan-20-one, also known as allopregnanolone, is a neurosteroid and a metabolite of progesterone. It acts as a potent positive allosteric modulator of the GABAA receptor, meaning it enhances the inhibitory effects of the neurotransmitter GABA in the brain. As a result, it has sedative, anxiolytic, and anticonvulsant properties, and has been investigated for its potential as a treatment for various neuropsychiatric disorders, including anxiety disorders, depression, and PTSD. Additionally, allopregnanolone has been studied for its potential role in promoting neurogenesis and neuroprotection. Overall, this chemical compound is of interest for its potential therapeutic applications in the field of neuropharmacology.
Check Digit Verification of cas no
The CAS Registry Mumber 53-40-7 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 5 and 3 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 53-40:
(4*5)+(3*3)+(2*4)+(1*0)=37
37 % 10 = 7
So 53-40-7 is a valid CAS Registry Number.
53-40-7Relevant articles and documents
Anesthetic activity of novel water-soluble 2β-morpholinyl steroids and their modulatory effects at GABA(A) receptors
Anderson, Alison,Boyd, Andrew C.,Byford, Alan,Campbell, Alexander C.,Gemmell, David K.,Hamilton, Niall M.,Hill, David R.,Hill-Venning, Claire,Lambert, Jeremy J.,Maidment, Maurice S.,May, Valerie,Marshall, Richard J.,Peters, John A.,Rees, David C.,Stevenson, Donald,Sundaram, Hardy
, p. 1668 - 1681 (1997)
(3α,5α)-3-Hydroxypregnan-20-ones and (3α,5α)-3-hydroxypregnane- 11,20-diones bearing a 2β-morpholinyl substituent were synthesized, and the utility of these steroids as anesthetic agents was evaluated through determination of their potency and duration of
