4,5,6-trichloro-1-(beta-D-ribofuranosyl)-1H-benzimidazole, also known as clofarabine, is a synthetic nucleoside analog with potent antiviral and anticancer properties. It is a water-soluble prodrug of the parent compound, 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)adenine (Cl-F-ara-A). Clofarabine is designed to mimic the structure of natural nucleosides, allowing it to be incorporated into DNA during replication, which ultimately leads to the termination of DNA synthesis and cell death. 4,5,6-trichloro-1-(beta-D-ribofuranosyl)-1H-benzimidazole is particularly effective against various types of leukemia and lymphoma, as it targets rapidly dividing cells. Clofarabine has been approved by the FDA for the treatment of pediatric patients with relapsed or refractory acute lymphoblastic leukemia and has shown promise in clinical trials for other types of cancer as well. Its mechanism of action involves the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable agent in the fight against cancer.
53-82-7
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Basic information
- Product Name: 4,5,6-trichloro-1-(beta-D-ribofuranosyl)-1H-benzimidazole
- Synonyms: 4,5,6-Trichloro-1-.beta.-D-ribofuranosylbenzimidazole; Benzimidazole, 4,5,6-trichloro-1-beta-D-ribofuranosyl-
- CAS NO:53-82-7
- Molecular Formula: C12H11Cl3N2O4
- Molecular Weight: 353.5857
- EINECS: N/A
- Product Categories: N/A
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Chemical Properties
- Melting Point: N/A
- Boiling Point: 629.9°C at 760 mmHg
- Flash Point: 334.7°C
- Appearance: N/A
- Density: 1.94g/cm3
- Vapor Pressure: 9.84E-17mmHg at 25°C
- Refractive Index: 1.76
- Storage Temp.: N/A
- Solubility: N/A
- PKA: 13.16±0.70(Predicted)
- CAS DataBase Reference: 4,5,6-trichloro-1-(beta-D-ribofuranosyl)-1H-benzimidazole(CAS DataBase Reference)
- NIST Chemistry Reference: 4,5,6-trichloro-1-(beta-D-ribofuranosyl)-1H-benzimidazole(53-82-7)
- EPA Substance Registry System: 4,5,6-trichloro-1-(beta-D-ribofuranosyl)-1H-benzimidazole(53-82-7)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 53-82-7(Hazardous Substances Data)
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Check Digit Verification of cas no
The CAS Registry Mumber 53-82-7 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 5 and 3 respectively; the second part has 2 digits, 8 and 2 respectively.Calculate Digit Verification of CAS Registry Number 53-82:
(4*5)+(3*3)+(2*8)+(1*2)=47
47 % 10 = 7
So 53-82-7 is a valid CAS Registry Number.
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4,5,6-trichloro-1-(beta-D-ribofuranosyl)-1H-benzimidazole
