530089-07-7Relevant articles and documents
Preparation of (4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-ylidene)acetamide derivatives as novel arginine vasopressin V2 receptor agonists
Tsukamoto, Issei,Koshio, Hiroyuki,Akamatsu, Seijiro,Kuramochi, Takahiro,Saitoh, Chikashi,Yatsu, Takeyuki,Yanai-Inamura, Hiroko,Kitada, Chika,Yamamoto, Eisaku,Sakamoto, Shuichi,Tsukamoto, Shin-ichi
experimental part, p. 9524 - 9535 (2009/04/05)
The present work describes the discovery of novel series of (4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepine-5-ylidene)acetamide derivatives as arginine vasopressin (AVP) V2 receptor agonists. By replacing the amide juncture in YM-35278 with a direct ring connection gave compound 10a, which acts as a V2 receptor agonist. These studies provided the potent, orally active non-peptidic V2 receptor agonists 10a and 10j.