53009-04-4Relevant academic research and scientific papers
Enantiopure DAVA-Derivatives-Part III. Synthesis of All 4 Stereoisomers of 2-Methyl-4-hydroxy-5-aminopentanoic Acid (2-Me-4-OH-DAVA)
Herdeis, Claus,Luetsch, Karen
, p. 121 - 131 (2007/10/02)
A stereoselective synthesis of the 4 stereoisomers of 2-methyl-4-hydroxy-5-amino-pentanoic acid namely 2R,4S-9a, 2S,4S-9b, ent-9a and ent-9b is presented, starting from the known lactones S-1 and R-1, which are readily avalaible from L- and D-glutamic acid.Only ent-9b shows affinity for GABAB-receptors sites.
