53013-43-7

Usage

Uses

Used in Pharmaceutical Industry:
1-(5-chloro-2-nitrophenyl)piperidine is used as a pharmaceutical compound for its potential to interact with biological systems. The presence of the piperidine ring, a common structural motif in many drugs, suggests that 1-(5-chloro-2-nitrophenyl)piperidine could be utilized in the development of new medications, possibly targeting specific receptors or enzymes within the body.
Used in Chemical Synthesis:
1-(5-chloro-2-nitrophenyl)piperidine is used as a starting material in chemical synthesis processes. The presence of the nitro and chloro groups on the phenyl ring provides opportunities for further chemical reactions, making 1-(5-chloro-2-nitrophenyl)piperidine a valuable intermediate in the production of other related compounds with potential applications in various fields.
Used in Research Applications:
1-(5-chloro-2-nitrophenyl)piperidine is used as a research tool in scientific studies. Its unique structure allows researchers to explore its properties and reactivity, potentially leading to new insights into chemical behavior and the development of novel synthetic pathways or applications in various industries.

Upstream product

• 110-89-4 piperidine 
• 64-17-5 ethanol 
• 610-40-2 3,4-dinitro-chlorobenzene 
• 611-06-3 2,4-dichloronitrobenzene 
• 700-37-8 4-chloro-2-fluoro-nitrobenzene 
• 121-73-3 3-Nitrochlorobenzene 

Downstream Products

• 854044-31-8 1-(5-methoxy-2-nitro-phenyl)-piperidine 
• 854044-33-0 1-(5-imidazol-1-yl-2-nitro-phenyl)-piperidine 
• 854044-40-9 1-(5-ethoxy-2-nitro-phenyl)-piperidine 
• 885704-43-8 4-(4-nitro-3-piperidin-1-yl-phenyl)-thiomorpholine 
• 885704-59-6 1-[5-(4-methyl-pyrazol-1-yl)-2-nitro-phenyl]-piperidine 
• 202279-91-2 4-nitro-3-piperidin-1-yl-phenylamine 
• 854044-43-2 N-Methyl-(4-nitro-3-piperidin-1-yl-phenyl)-amine 
• 885703-64-0 5-cyano-N-(4-(4-methylpiperazin-1-yl)-2-(piperidin-1-yl)phenyl)furan-2-carboxamide 
• 53013-41-5 4-(2-nitro-5-piperidinophenyl)piperidine 
• 353501-02-7 1-methyl-4-(4-nitro-3-(piperidin-1-yl)phenyl)piperazine 

Relevant academic research and scientific papers

POSITRON EMISSION TOMOGRAPHY (PET) RADIOTRACERS FOR IMAGING MACROPHAGE COLONY-STIMULATING FACTOR 1 RECEPTOR (CSF1R) IN NEUROINFLAMMATION

Positron emission tomography (PET) radiotracers for imaging macrophage colony stimulating factor-1 receptors in a subject afflicted with or suspected of being afflicted with a neuroinflammatory or neurodegenerative disease or disorder are disclosed.

Ortho selectivity in SNAr substitutions of 2,4-dihaloaromatic compounds. Reactions with piperidine

A broad survey of aromatic compounds with halogens positioned both ortho and para to activating groups was studied in SNAr reactions with piperidine. Regioselectivities varied with the substituent group and the polarity of the solvent. Many act

Discovery of novel FMS kinase inhibitors as anti-inflammatory agents

The optimization of the arylamide lead 2 resulted in identification of a highly potent series of 2,4-disubstituted arylamides. Compound 8 (FMS kinase IC50 = 0.0008 μM) served as a proof-of-concept candidate in a collagen-induced model of arthri

AROMATIC AMIDES AS INHIBITORS OF C-FMS KINASE

The invention relates to compounds of Formula (I), wherein A, X, R2 and W are set forth in the specification, as well as solvates, hydrates, tautomers and pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase. Methods of treating autoimmune diseases; and diseases with an inflammatory component; treating metastasis from ovarian cancer, uterine cancer, breast cancer, colon cancer, stomach cancer, hairy cell leukemia and non-small lung carcinoma; and treating pain, including skeletal pain caused by tumor metastasis or osteoarthritis, or visceral, inflammatory, and neurogenic pain; as well as osteoporosis, Paget's disease, and other diseases in which bone resorption mediates morbidity including arthritis, prosthesis failure, osteolytic sarcoma, myeloma, and tumor metastasis to bone with the compounds of Formula (I), are also provided.

C-fms kinase inhibitors

The invention is directed to compounds of Formulae I: wherein A, R1, R2, R3, R4, X, and W are set forth in the specification, as well as solvates, hydrates, tautomers or pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase.

Specific features of nucleophilic substitution in 1-chloro-3,4- dinitrobenzene

Effects of the solvent, temperature, and nucleophile nature on the selectivity of nucleophilic substitution in 1-chloro-3,4-dinitrobenzene were studied, and optimal conditions were found for the synthesis and isolation of particular products.