53013-43-7

Basic information

• Product Name: 1-(5-chloro-2-nitrophenyl)piperidine
• Synonyms: 1-(5-chloro-2-nitrophenyl)piperidine
• CAS NO: 53013-43-7
• Molecular Formula: C₁₁H₁₃ClN₂O₂
• Molecular Weight: 240.69
• Mol File: 53013-43-7.mol
• Article Data: 6

Chemical Properties

• Melting Point: 69-70°
• Appearance: /
• CAS DataBase Reference: 1-(5-chloro-2-nitrophenyl)piperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(5-chloro-2-nitrophenyl)piperidine(53013-43-7)
• EPA Substance Registry System: 1-(5-chloro-2-nitrophenyl)piperidine(53013-43-7)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 53013-43-7(Hazardous Substances Data)

Usage

General Description

1-(5-chloro-2-nitrophenyl)piperidine is a chemical compound comprised of a piperidine ring with a 5-chloro-2-nitrophenyl group attached. It is an organic compound with potential applications in pharmaceuticals and research. This chemical may have pharmaceutical uses due to its potential to interact with biological systems and its structure containing a piperidine ring, which is a common structural motif in drugs. Additionally, the presence of the nitro and chloro groups could make this compound useful in chemical synthesis and as a starting material for the production of other compounds. However, as with any chemical, it should be handled with care and proper safety precautions should be taken when working with it.

Upstream product

• 110-89-4 piperidine 
• 64-17-5 ethanol 
• 610-40-2 3,4-dinitro-chlorobenzene 
• 121-73-3 3-Nitrochlorobenzene 
• 700-37-8 4-chloro-2-fluoro-nitrobenzene 
• 611-06-3 2,4-dichloronitrobenzene 

Downstream Products

• 53013-41-5 4-(2-nitro-5-piperidinophenyl)piperidine 
• 885704-59-6 1-[5-(4-methyl-pyrazol-1-yl)-2-nitro-phenyl]-piperidine 
• 885703-64-0 5-cyano-N-(4-(4-methylpiperazin-1-yl)-2-(piperidin-1-yl)phenyl)furan-2-carboxamide 
• 854044-43-2 N-Methyl-(4-nitro-3-piperidin-1-yl-phenyl)-amine 
• 854044-40-9 1-(5-ethoxy-2-nitro-phenyl)-piperidine 
• 202279-91-2 4-nitro-3-piperidin-1-yl-phenylamine 
• 885704-43-8 4-(4-nitro-3-piperidin-1-yl-phenyl)-thiomorpholine 
• 854044-33-0 1-(5-imidazol-1-yl-2-nitro-phenyl)-piperidine 
• 854044-31-8 1-(5-methoxy-2-nitro-phenyl)-piperidine 
• 353501-02-7 1-methyl-4-(4-nitro-3-(piperidin-1-yl)phenyl)piperazine 

Relevant articles and documents

POSITRON EMISSION TOMOGRAPHY (PET) RADIOTRACERS FOR IMAGING MACROPHAGE COLONY-STIMULATING FACTOR 1 RECEPTOR (CSF1R) IN NEUROINFLAMMATION

Positron emission tomography (PET) radiotracers for imaging macrophage colony stimulating factor-1 receptors in a subject afflicted with or suspected of being afflicted with a neuroinflammatory or neurodegenerative disease or disorder are disclosed.

Discovery of novel FMS kinase inhibitors as anti-inflammatory agents

The optimization of the arylamide lead 2 resulted in identification of a highly potent series of 2,4-disubstituted arylamides. Compound 8 (FMS kinase IC50 = 0.0008 μM) served as a proof-of-concept candidate in a collagen-induced model of arthri

C-fms kinase inhibitors

The invention is directed to compounds of Formulae I: wherein A, R1, R2, R3, R4, X, and W are set forth in the specification, as well as solvates, hydrates, tautomers or pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase.