530141-40-3

Usage

Uses

Used in Organic Synthesis:
2-(TRIFLUOROMETHOXY)PHENACYL BROMIDE is used as a reagent for the synthesis of various organic compounds, particularly in the preparation of novel pharmaceutical and agrochemical products. Its unique structure and reactivity make it a valuable component in the development of new chemical entities.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 2-(TRIFLUOROMETHOXY)PHENACYL BROMIDE is utilized as a key intermediate in the synthesis of potential drug candidates. Its chemical properties allow for the creation of new molecules with therapeutic potential, contributing to the advancement of medicinal chemistry.
Used in Agrochemical Development:
Similarly, in agrochemical research, 2-(TRIFLUOROMETHOXY)PHENACYL BROMIDE serves as a reagent in the synthesis of new compounds with pesticidal or herbicidal properties, aiming to improve crop protection and yield.
Used in Material Science:
2-(TRIFLUOROMETHOXY)PHENACYL BROMIDE is also employed in the development of new materials, where its chemical versatility aids in the creation of innovative substances with unique properties for various applications.
Used in Chemical Process Development:
In the field of chemical process development, 2-(TRIFLUOROMETHOXY)PHENACYL BROMIDE is utilized to optimize and innovate existing processes, enhancing the efficiency and selectivity of chemical reactions in research and industrial settings.

Upstream product

• 220227-93-0 1-(2-(trifluoromethoxy)phenyl)ethan-1-one 

Downstream Products

• 868851-38-1 3-oxo-2-[2-oxo-2-(2-trifluoromethoxy-phenyl)-ethyl]-butyric acid methyl ester 
• 1015756-71-4 C₁₂H₇F₃N₂OS 

Relevant academic research and scientific papers

Agonist-mediated switching of ion selectivity in TPC2 differentially promotes lysosomal function

Ion selectivity is a defining feature of a given ion channel and is considered immutable. Here we show that ion selectivity of the lysosomal ion channel TPC2, which is hotly debated (Calcraft et al., 2009; Guo et al., 2017; Jha et al., 2014; Ruas et al., 2015; Wang et al., 2012), depends on the activating ligand. A high-throughput screen identified two structurally distinct TPC2 agonists. One of these evoked robust Ca2+-signals and non-selective cation currents, the other weaker Ca2+-signals and Na+-selective currents. These properties were mirrored by the Ca2+- mobilizing messenger, NAADP and the phosphoinositide, PI(3,5)P2, respectively. Agonist action was differentially inhibited by mutation of a single TPC2 residue and coupled to opposing changes in lysosomal pH and exocytosis. Our findings resolve conflicting reports on the permeability and gating properties of TPC2 and they establish a new paradigm whereby a single ion channel mediates distinct, functionally-relevant ionic signatures on demand.

AROMATIC HETEROCYCLIC COMPOUND

The compound represented by the general formula: wherein ring A is benzene which may be substituted and the like; ring B is benzene which may be substituted and the like; X is a single bond and the like; Y is alkyl which may be substituted and the like; Z is CR1 or nitrogen atom; R1 is hydrogen and the like; R2 is alkyl which may be substituted and the like or a pharmaceutically acceptable salt thereof is useful as a prevention/treatment agent of obesity, diabetes, and the like.

Thiadiazinones

Compounds of formula I STR1 in which R1 and R2 are each independently of one another H or A, R3 is H, OA or O--Cm H2m+1-n Xn, R4 is --O--Cm H2m+1-n Xn, X is F or Cl, A is alkyl having 1-6 C atoms, m is 1, 2, 3, 4, 5 or 6 and n is 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 or 13, and their salts have positive ionitropic activity and vasodilating action, and promote circulation. In addition, the compounds can be employed for the treatment of asthmatic disease and memory disorders, and have anti-depressive and anti-inflammatory properties.