530151-58-7Relevant academic research and scientific papers
Synthesis of metal-chelating lipids to sensitize lanthanide ions
Roy, Bidhan C.,Santos, Marina,Mallik, Sanku,Campiglia, Andres D.
, p. 3999 - 4007 (2003)
Sensitization of lanthanide ions is important for lanthanide ion-based assays and sensing. To the best of our knowledge, there are very few reports of lanthanide ion sensitization after it is incorporated into the liposome surface. This paper describes the syntheses of several saturated and polymerizable metal-chelating lipids based on chelidamic acid. The lipids are synthesized either from (S)-ornithine or racemic 2,3-diaminopropanoic acid. These lipids as well as polymerized liposomes incorporating these lipids sensitize lanthanide ions. Liposomes from the lipid 18-Eu3+ provided a probe that relies not only on the emission wavelengths of Eu3+ but also on a reproducible lifetime that can be used for protein identification.
