53047-74-8

Basic information

• Product Name: C₁₉H₂₀N₄
• CAS NO: 53047-74-8
• Molecular Weight: 304.395
• Mol File: 53047-74-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₉H₂₀N₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₉H₂₀N₄(53047-74-8)
• EPA Substance Registry System: C₁₉H₂₀N₄(53047-74-8)

Safety Data

• Hazardous Substances Data: 53047-74-8(Hazardous Substances Data)

Upstream product

• 109-01-3 1-methyl-piperazine 
• 7065-92-1 2-chloro-3-phenylquinoxaline 

Relevant articles and documents

Fragment based design of new H4 receptor-ligands with anti-inflammatory properties in vivo

Using a previously reported flexible alignment model we have designed, synthesized, and evaluated a series of compounds at the human histamine H 4 receptor (H4R) from which 2-(4-methyl-piperazin-l-yl)- quinoxaline (3) was identified as a new lead structure for H4R ligands. Exploration of the structure-activity relationship (SAR) of this scaffold led to the identification of 6,7-dichloro 3-(4-methylpiperazin-l-yl) quinoxalin-2(1H)-one (VUF 10214, 57) and 2-benzyl-3-(4-methyl-piperazin-l-yl) quinoxaline (VUF 10148, 20) as potent H4R ligands with nanomolar affinities. In vivo studies in the rat reveal that compound 57 has significant anti-inflammatory properties in the carrageenan-induced paw-edema model.