5305-44-2

Basic information

• Product Name: 4,6-dichloro-5-(1,3-dioxolan-2-yl)pyriMidine
• Synonyms: 4,6-dichloro-5-(1,3-dioxolan-2-yl)pyriMidine
• CAS NO: 5305-44-2
• Molecular Formula: C₇H₆Cl₂N₂O₂
• Molecular Weight: 221.04074
• Mol File: 5305-44-2.mol
• Article Data: 5

Chemical Properties

• Melting Point: 104-105 °C
• Boiling Point: 300.9±42.0 °C(Predicted)
• Appearance: /
• Density: 1.520±0.06 g/cm3(Predicted)
• PKA: -4.58±0.26(Predicted)
• CAS DataBase Reference: 4,6-dichloro-5-(1,3-dioxolan-2-yl)pyriMidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4,6-dichloro-5-(1,3-dioxolan-2-yl)pyriMidine(5305-44-2)
• EPA Substance Registry System: 4,6-dichloro-5-(1,3-dioxolan-2-yl)pyriMidine(5305-44-2)

Safety Data

• Hazardous Substances Data: 5305-44-2(Hazardous Substances Data)

Upstream product

• 107-21-1 ethylene glycol 
• 5305-40-8 2,6-dichloro-pyrimidine carbaldehyde 

Downstream Products

• 5604-44-4 4-acetylamino-N-(6-chloro-5-[1,3]dioxolan-2-yl-pyrimidin-4-yl)-benzenesulfonamide 
• 733749-78-5 4-chloro-5-[1,3]dioxolan-2-yl-6-(4-[1,2,3]thiadiazol-4-yl-phenoxy)-pyrimidine 
• 5604-45-5 4-amino-N-(5-[1,3]dioxolan-2-yl-6-methoxy-pyrimidin-4-yl)-benzenesulfonamide 

Relevant articles and documents

NOVEL BENZYLAMINO SUBSTITUTED PYRIDOPYRIMIDINONES AND DERIVATIVES AS SOS1 INHIBITORS

The present invention encompasses compounds of formula (I) wherein the groups R1 to R4, A and p have the meanings given in the claims and specification, their use as inhibitors of SOS1, pharmaceutical compositions which contain compounds of this kind and their use as medicaments/medical uses, especially as agents for treatment and/or prevention of oncological diseases.

Synthesis of hexahydrobenzo[ b ]pyrimido[4,5- h ][1,6]naphthyridines via an intramolecular hetero-diels-alder reaction

Method development was completed for a strategy to access a novel pyrimidine-fused heterocyclic scaffold. The key step for this synthetic route entails an intramolecular inverse electron demand hetero-Diels-Alder reaction of imines or iminiums formed in situ from allylaminopyrimidinealdehydes 3 and anilines. The reactions provided exclusively cis-configuration products 6. Products 6 were readily precipitated in the reaction solution in good to excellent yields. Further transformations of the phenylthio group were demonstrated by an oxidation and subsequent nucleophilic substitution sequence. The synthetic strategy provides an efficient way to access libraries of the tetracyclic pyrimidine-fused heterocycles that can be explored for potential pharmaceutical or biological activities.

1,2,3-TRISUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PRPPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO SUCH AS DIABETES AND HYPERGLYCEMIA

The present invention relates to certain 1,2,3-trisubstituted aryl and heteroaryl derivatives of Fomula (Ia) that are modulators of metabolism. Accordingly, compounds of the present invention are useful in the prophylaxis or treatment of metabolic disorde