5307-02-8

Basic information

• Product Name: 1,4-diamino-2-methoxybenzene
• Synonyms: 1,4-diamino-2-methoxybenzene;1-METHOXY-2,5-DIAMINOBENZENE;PARA-DIAMINOANISOLE;2-METHOXY-PARA-PHENYLENEDIAMINE;2-Methoxy-1,4-benzenediamine;2-Methoxy-1,4-diaminobenzene;2-Methoxy-1,4-phenylenediamine
• CAS NO: 5307-02-8
• Molecular Formula: C₇H₁₀N₂O
• Molecular Weight: 138.19
• EINECS: 226-161-9
• Mol File: 5307-02-8.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 253.57°C (rough estimate)
• Flash Point: 159°C
• Appearance: /
• Density: 1.1315 (rough estimate)
• Vapor Pressure: 0.00122mmHg at 25°C
• Refractive Index: 1.5780 (estimate)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 1,4-diamino-2-methoxybenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-diamino-2-methoxybenzene(5307-02-8)
• EPA Substance Registry System: 1,4-diamino-2-methoxybenzene(5307-02-8)

Safety Data

• Hazardous Substances Data: 5307-02-8(Hazardous Substances Data)

Usage

Physical state

Colorless to yellow solid

Uses

Production of dyes, pharmaceuticals, and polymers

Chemical properties

Aromatic

Role

Intermediate in the synthesis of various organic compounds

Safety precautions

Harmful if swallowed or inhaled, causes skin and eye irritation

Industrial applications

Crucial role in various industries due to its versatility

InChI:InChI=1/C7H10N2O/c1-10-7-4-5(8)2-3-6(7)9/h2-4H,8-9H2,1H3

Upstream product

• 792859-06-4 C₇H₈N₂O 
• 51837-64-0 N,N'-(methoxy-p-phenylene)-bis-acetamide 
• 97-52-9 2-methoxy-4-nitrophenylamine 
• 66671-82-7 2-methoxy-1,4-phenylenediamine sulfate 

Downstream Products

• 66608-32-0 3-Methoxy-N,N'-bis-(N-diethoxyphosphoryl-thiocarbamoyl)-1,4-phenylendiamin 
• 524040-13-9 1,12-(2-methoxy-1,4-phenylene)bis(1H-tetrazole) 
• 792859-06-4 C₇H₈N₂O 
• 97-52-9 2-methoxy-4-nitrophenylamine 
• 855881-77-5 N,N'-(2-methoxy-5-nitro-p-phenylene)-bis-acetamide 
• 855230-76-1 N,N'-(2-methoxy-5-phenylsulfanyl-p-phenylene)-bis-benzenesulfonamide 
• 83202-21-5 methoxybenzoquinone bis(benzenesulfonimide) 
• 171368-24-4 C₄₂H₃₀N₄O₇S 
• 84-12-8 phanquinone 
• 165817-09-4 Acetic acid 5-(allyl-benzenesulfonyl-amino)-1-benzenesulfonyl-4-iodo-6-methoxy-2,3-dihydro-1H-indol-3-ylmethyl ester 
• 165817-13-0 (1RS)-6-Benzenesulfonyl-3-benzenesulfonyl-5-methoxy-1-acetoxymethyl-8-methylidene-1,2,7,8-tetrahydro-6H-pyrrolo[3,2-e]indole 
• 165817-15-2 (1RS)-6-Benzenesulfonyl-3-benzenesulfonyl-5-methoxy-1-acetoxymethyl-8-methyl-1,2-dihydro-3H-pyrrolo[3,2-e]indole 

Relevant articles and documents

Self-Assembled Magnetic Gold Catalysts from Dual-Functional Boron Clusters

A new class of core–shell magnetic gold nanocomposites is prepared in a raspberry-like fashion by the controlled supramolecular host–guest assembly of γ-cyclodextrins (γ-CDs) and boron clusters. In this work, Cs2[closo-B12H12], a fundamental boron cluster, can play a dual role in the preparation of highly monodispersed Au nanoparticles and in the immobilization of Au nanoparticles on the γ-CDs@Fe3O4 surface as an effective anchor. This facile and spontaneous supramolecular strategy allows for the control of the size and composition of the highly stable gold composites. Furthermore, the obtained AuNPs@Fe3O4 composites exhibit an excellent catalytic activity and recyclability for the selective reduction of nitroaromatics to their corresponding aniline compounds, and the fastest reaction can be achieved within 20 s with a high conversion and selectivity at room temperature, which is better than that obtained previously in studies on metal nanoparticle composites as catalysts.

Structure-Activity and Structure-Property Relationship and Exploratory in Vivo Evaluation of the Nanomolar Keap1-Nrf2 Protein-Protein Interaction Inhibitor

Directly disrupting the Keap1-Nrf2 protein-protein interaction (PPI) is an effective way to activate Nrf2. Using the potent Keap1-Nrf2 PPI inhibitor that was reported by our group, we conducted a preliminary investigation of the structure-activity and structure-property relationships of the ring systems to improve the drug-like properties. Compound 18e, which bore p-acetamido substituents on the side chain phenyl rings, was the best choice for balancing PPI inhibition activity, physicochemical properties, and cellular Nrf2 activity. Cell-based experiments with 18e showed that the Keap1-Nrf2 PPI inhibitor can activate Nrf2 and induce the expression of Nrf2 downstream proteins in an Nrf2-dependent manner. An exploratory in vivo experiment was carried out to further evaluate the anti-inflammatory effects of 18e in a LPS-challenged mouse model. The primary results indicated that 18e could reduce the level of circulating pro-inflammatory cytokines induced by LPS and relieve the inflammatory response. (Chemical Equation Presented).

One step hair coloring compositions using salts

A hair coloring composition comprising the following two compositions which are mixed just prior to application to the hair: (a) a composition comprising a water-soluble peroxygen oxidizing agent; and (b) a composition comprising one or more oxidative hair coloring agents selected from the group consisting of an aromatic diamine, an amino phenol, a naphthol, a polyhydric phenol, a catechol and mixtures thereof; wherein the composition comprising one or more oxidative hair coloring agents further comprises al least one water soluble carbonate releasing salts; and optionally a water soluble ammonium salt, is described.