530739-47-0Relevant academic research and scientific papers
Total syntheses of four possible stereoisomers of resolvin E3
Urabe, Daisuke,Todoroki, Hidenori,Masuda, Koji,Inoue, Masayuki
, p. 3210 - 3219 (2012/06/01)
Resolvin E3, 17,18-dihydroxy-5Z,8Z,11Z,13E,15E-eicosapentaenoic acid, is a potent anti-inflammatory lipid mediator. To determine the stereochemistries of the C17- and C18-hydroxy groups of resolvin E3 and to supply a sufficient amount of material for futu
Zn-catalyzed asymmetric allylation for the synthesis of optically active allylglycine derivatives. Regio- and stereoselective formal α-addition of allylboronates to hydrazono esters
Fujita, Mari,Nagano, Takashi,Schneider, Uwe,Hamada, Tomoaki,Ogawa, Chikako,Kobayashi, Shu
, p. 2914 - 2915 (2008/10/09)
We have developed Zn-catalyzed asymmetric allylation of hydrazono esters with allylboronates. The reactions proceeded smoothly in high yields and high stereoselectivities. Remarkably, formal α-addition occurred for α-substituted allylboronates exclusively, and excellent stereoselectivities were observed. This is the first example of catalytic regio- and stereoselective allylations with formal α-addition. In addition, the reaction proceeded in aqueous media, and the use of water is essential. Zn(OH)2 might be a catalyst in this asymmetric allylation, and the catalytic activity of Zn(OH)2 was confirmed. This is also the first case of chiral metal hydroxide-catalyzed asymmetric reactions. Copyright
Asymmetric synthesis of (-)-α-conhydrine
Kandula, Subba Rao V.,Kumar, Pradeep
, p. 3268 - 3274 (2007/10/03)
The enantioselective synthesis of (-)-α-conhydrine has been achieved by two different synthetic routes. The key steps include Sharpless asymmetric dihydroxylation, regioselective opening of a cyclic sulfate and Wittig olefination.
Enantioselective synthesis of (-)-α-conhydrine via cyclic sulfate methodology
Kandula, SubbaRao V.,Kumar, Pradeep
, p. 1957 - 1958 (2007/10/03)
An asymmetric synthesis of (-)-α-conhydrine is described using the Sharpless asymmetric dihydroxylation and the regiospecific nucleophilic opening of a cyclic sulfate as the key steps.
