53118-46-0

Usage

Uses

Used in Organic Synthesis:
(1E)-bis(3,4-dichlorobenzylidene)hydrazine is used as a reagent in organic synthesis for the preparation of various chemical compounds.
Used in Pharmaceutical Industry:
(1E)-bis(3,4-dichlorobenzylidene)hydrazine is used as a building block in the development of pharmaceuticals due to its potential applications in drug discovery and design.
Used in Agrochemicals:
(1E)-bis(3,4-dichlorobenzylidene)hydrazine is used as a precursor in the synthesis of agrochemicals, contributing to the development of pesticides and other agricultural products.
Used in Materials Science:
(1E)-bis(3,4-dichlorobenzylidene)hydrazine is used as a component in the research and development of new materials with specific properties for various applications.
Note: Due to its potential toxicity and hazardous nature, (1E)-bis(3,4-dichlorobenzylidene)hydrazine must be handled with care and in accordance with proper safety protocols.

Upstream product

• 691-38-3 (Z)-4-methyl-2-pentene 
• 110-82-7 cyclohexane 
• 125564-01-4 1-(3,4-dichlorophenyl)-4-methyl-1-penten-3-one 
• 6287-38-3 3,4-dichlorobenzaldehyde 

Downstream Products

• 1166381-79-8 3,3-dimethyl-7,11-di(3,4-dichlorophenyl)-2,4-dioxaspiro[5,5]undecane-1,5,9-trione 
• 1166381-87-8 7,14-bis(3,4-dichlorophenyl)-11,11-dimethyl-1,4,10,12-tetraoxadispiro[4.2.5.2]pentadecane-9,13-dione 

Relevant academic research and scientific papers

An expeditious synthetic approach towards the synthesis of Bis-Schiff bases (aldazines) using ultrasound

Aldazines (Bis-Schiff bases) 1-24 were synthesized using aromatic aldehydes (heterocyclic and benzaldehydes) and hydrazine hydrate under reflux using conventional heating and/or via ultrasound irradiation using BiCl3 as catalyst. Ultrasonication conditions with cat. BiCl3 proved to be an effective, environmentally friendly synthetic procedure. This methodology is robust in the presence of electron donating and electron withdrawing groups affording desired products with high yields (>95%) in just a couple of minutes vs. hours using conventional heating.

Synthesis and cytotoxic evaluation of some styryl ketones and related compounds

A number of 1-aryl-4-methyl-1-penten-3-ones 1 were converted to the corresponding Mannich bases 2 and analogues 3.Attempts to form the azines 4 from several members in series 1 led to the isolation of the corresponding pyrazolines 5 or aryl aldehyde azine

THE EFFECT OF ARYL SUBSTITUENTS ON ARYLCARBENE REACTIVITY

Substituted (p-MeO, p-Me, H, p-Cl, p-Br, m-Br, m-MeO, 3,4-Cl2, p-CO2Me, m-CN and p-CN) monophenylcarbenes are generated in a binary mixture of substrates (methanol, cis-4-methyl-2-pentene and cyclohexane) and the relative rate of O - H insertion into methanol to stereospecific cyclopropanation of the olefin to C - H insertion into cyclohexane are calculated from the ratios of products and substrates.It is found (i) that the reactivities of the substrates decrease in the order of methanol, olefin and cyclohexane and (ii) that electron-donating substituents generally lead to reaction with the more reactive substrates while the reaction with the less reactive substrates is favoured in the case of electron-withdrawing substituents.These results are interpreted in terms of the change in the electrophilicity of the singlet arylcarbene by the substituents rather than the change in the singlet-triplet equilibrium.