53122-04-6

Basic information

• Product Name: (5Z,13E,15S)-15-[[(tert-Butyl)dimethylsilyl]oxy]-9-oxo-5,10,13-prostatrien-1-oic acid methyl ester
• Synonyms: (5Z,13E,15S)-15-[[(tert-Butyl)dimethylsilyl]oxy]-9-oxo-5,10,13-prostatrien-1-oic acid methyl ester
• CAS NO: 53122-04-6
• Molecular Formula: C₂₇H₄₆O₄Si
• Molecular Weight: 462.74
• Mol File: 53122-04-6.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (5Z,13E,15S)-15-[[(tert-Butyl)dimethylsilyl]oxy]-9-oxo-5,10,13-prostatrien-1-oic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (5Z,13E,15S)-15-[[(tert-Butyl)dimethylsilyl]oxy]-9-oxo-5,10,13-prostatrien-1-oic acid methyl ester(53122-04-6)
• EPA Substance Registry System: (5Z,13E,15S)-15-[[(tert-Butyl)dimethylsilyl]oxy]-9-oxo-5,10,13-prostatrien-1-oic acid methyl ester(53122-04-6)

Safety Data

• Hazardous Substances Data: 53122-04-6(Hazardous Substances Data)

Upstream product

• 13345-50-1 prostaglandin A₂ 
• 31753-19-2 (5Z,13E)-15-hydroxy-9-oxoprosta 5,10,13 trien-1-oic acid 
• 18162-48-6 tert-butyldimethylsilyl chloride 

Downstream Products

• 74271-59-3 (Z)-7-{(1R,6S)-2-[(E)-(S)-3-(tert-Butyl-dimethyl-silanyloxy)-oct-1-enyl]-4,6-dihydroxy-cyclohexyl}-hept-5-enoic acid methyl ester 
• 74271-56-0 (Z)-7-{(R)-6-[(E)-(S)-3-(tert-Butyl-dimethyl-silanyloxy)-oct-1-enyl]-2-oxo-cyclohex-3-enyl}-hept-5-enoic acid methyl ester 
• 74271-55-9 (R)-5-[(E)-(S)-3-(tert-Butyl-dimethyl-silanyloxy)-oct-1-enyl]-6-((Z)-7-hydroxy-hept-2-enyl)-cyclohex-3-enone 
• 87727-97-7 (1S,3R,4R,5R)-4-[(E)-(S)-3-(tert-Butyl-dimethyl-silanyloxy)-oct-1-enyl]-5-[(E)-3-(4-methoxy-phenyl)-allyl]-cyclopentane-1,3-diol 
• 87692-43-1 (1S,3R,4R,5R)-4-[(E)-(S)-3-(tert-Butyl-dimethyl-silanyloxy)-oct-1-enyl]-5-[(Z)-3-(4-methoxy-phenyl)-allyl]-cyclopentane-1,3-diol 
• 87692-35-1 (2R,3R)-3-[(E)-(S)-3-(tert-Butyl-dimethyl-silanyloxy)-oct-1-enyl]-2-[(E)-3-(4-methoxy-phenyl)-allyl]-cyclopentanone 
• 87727-95-5 (2R,3R)-3-[(E)-(S)-3-(tert-Butyl-dimethyl-silanyloxy)-oct-1-enyl]-2-[(Z)-3-(4-methoxy-phenyl)-allyl]-cyclopentanone 
• 87727-98-8 (1S,3R,4R,5R)-4-((E)-(S)-3-Hydroxy-oct-1-enyl)-5-[(E)-3-(4-methoxy-phenyl)-allyl]-cyclopentane-1,3-diol 
• 87692-44-2 (1S,3R,4R,5R)-4-((E)-(S)-3-Hydroxy-oct-1-enyl)-5-[(Z)-3-(4-methoxy-phenyl)-allyl]-cyclopentane-1,3-diol 
• 87692-33-9 (1S,2R,3R)-3-[(E)-(S)-3-(tert-Butyl-dimethyl-silanyloxy)-oct-1-enyl]-2-[(E)-3-(4-methoxy-phenyl)-allyl]-cyclopentanol 
• 87727-93-3 (1S,2R,3R)-3-[(E)-(S)-3-(tert-Butyl-dimethyl-silanyloxy)-oct-1-enyl]-2-[(Z)-3-(4-methoxy-phenyl)-allyl]-cyclopentanol 
• 87692-34-0 (1S,2R,3R)-3-((E)-(S)-3-Hydroxy-oct-1-enyl)-2-[(E)-3-(4-methoxy-phenyl)-allyl]-cyclopentanol 
• 87727-94-4 (1S,2R,3R)-3-((E)-(S)-3-Hydroxy-oct-1-enyl)-2-[(Z)-3-(4-methoxy-phenyl)-allyl]-cyclopentanol 
• 87692-36-2 (2R,3R)-3-((E)-(S)-3-Hydroxy-oct-1-enyl)-2-[(E)-3-(4-methoxy-phenyl)-allyl]-cyclopentanone 

Relevant articles and documents

Identification of a crucial substructural unit for thromboxane A2 receptor binding

A stereospecific synthesis of the 9α,10α-epoxyprostanoic acid derivative 3, a potent and stable mimic of thromboxane A2, is described.

Synthesis of Aromatic Modified Prostaglandins from PGA2

A general synthetic scheme, starting from PGA2 (obtained from the marine coral Plexaura homomalla), of prostaglandins modified in the upper chain is detailed.Key aldehyde intermediates have been secured from 11-deoxy-PGF2α and PGF2α by an efficient regioselective hydroxylation procedure followed by cleavage of the 5,6-double bond.Witting reaction with these aldehydes provided the novel prostaglandins (5)-(8), belonging to the E and F families, and containing an aromatic ring in the upper chain.