53157-46-3

Basic information

• Product Name: 2-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-1H-isoindole-1,3(2H)-dione
• Synonyms: 2-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-1H-isoindole-1,3(2H)-dione
• CAS NO: 53157-46-3
• Molecular Formula: C₁₈H₁₄N₂O₃
• Molecular Weight: 306.31536
• Mol File: 53157-46-3.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-1H-isoindole-1,3(2H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-1H-isoindole-1,3(2H)-dione(53157-46-3)
• EPA Substance Registry System: 2-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-1H-isoindole-1,3(2H)-dione(53157-46-3)

Safety Data

• Hazardous Substances Data: 53157-46-3(Hazardous Substances Data)

Upstream product

• 85-44-9 phthalic anhydride 
• 608-07-1 2-(5-methoxyindol-3-yl)ethylamine 
• 55747-66-5 2-[2-(5-methoxy-1H-indol-3-yl)-ethyl]-isoindole-1,3-dione 
• 50-67-9 3-(2-aminoethyl)-1H-indol-5-ol 
• 23197-23-1 4-hydroxyphenylhydrazine 
• 32464-55-4 2-(4,4-diethoxybutyl)isoindoline-1,3-dione 
• 61-47-2 serotonin creatinine sulfate monohydrate 
• 22509-74-6 N-ethoxycarbonylphthalimide 

Downstream Products

• 374807-98-4 1-[3-[2-(N,N-phthalimido)ethyl]-1H-indol-3-yloxy]-3,6-dioxa-8-(4-methoxybenzylthio)octane 
• 50-67-9 3-(2-aminoethyl)-1H-indol-5-ol 
• 374807-97-3 1-[3-(2-aminoethyl)-1H-indol-3-yloxy]-3,6-dioxa-8-(4-methoxybenzylthio)octane 

Relevant articles and documents

Structural understanding of 5-(4-hydroxy-phenyl)-N-(2-(5-methoxy-1H-indol-3-yl)-ethyl)-3-oxopentanamide as a neuroprotectant for Alzheimer's disease

In our continuing efforts to develop novel neuroprotectants for Alzheimer's disease (AD), a series of analogs based on a lead compound that was recently shown to target the mitochondrial complex I were designed, synthesized and biologically characterized to understand the structure features that are important for neuroprotective activities. The results from a cellular AD model highlighted the important roles of the 4-OH on the phenyl ring and the 5-OCH3 on the indole ring of the lead compound. The results also demonstrated that the β-keto moiety can be modified to retain or improve the neuroprotective activity. Docking studies of selected analogs to the FMN site of mitochondrial complex I also supported the observed neuroprotective activities. Collectively, the results provide further information to guide optimization and development of analogs based on this chemical scaffold as neuroprotectants with a novel mechanism of action for AD.

The discovery of tetrahydro-β-carbolines as inhibitors of the kinesin Eg5

A series of tetrahydro-β-carbolines were identified by HTS as inhibitors of the kinesin Eg5. Molecular modeling and medicinal chemistry techniques were employed to explore the SAR for this series with a focus of removing potential metabolic liabilities and improving cellular potency.

5-HT(1D) receptor agonist properties of novel 2-[5- [[(trifluoromethyl)sulfonyl]oxy]indolyl]ethylamines and their use as synthetic intermediates

2-[5-[[(Trifluoromethyl)sulfonyl]oxy]-1H-indol-3-yl]ethylamine (18), its N,N'-di-n-propyl (12), N,N-diethyl (13), and N,N-dimethyl (14) derivatives, and 4-[3-[2-(N,N-dimethylamino)ethyl]-1H-indol-3-yl]-N-(p- methoxybenzyl)acrylamide (GR46611, 19) were syn