53165-17-6

Upstream product

• 2941-78-8 2-Amino-5-methylbenzoic acid 
• 1158910-14-5 N-(2-hydroxymethyl-4-methyl-phenyl)-acetamide 
• 1196-79-8 2,5-Dimethyl-1H-indole 

Downstream Products

• 4053-34-3 6-methylquinolin-2(1H)-one 
• 1003024-69-8 methyl 3-(2-acetamido-5-methylphenyl)-3-hydroxy-2-methylenepropanoate 

Relevant academic research and scientific papers

A Convenient Formal [4+2] Heterocylization Route to Bis(triflyl)tetrahydroquinolines

We report the sustainable and efficient synthesis of a new type of quinoline derivatives bearing one or two SO2CF3 groups. The protocol is metal-, catalyst- and irradiation-free, involves the use of readily available and stable precursors, and avoids the formation of side products. Also, the mild conditions of the process allow the tolerance of a wide range of functional groups.

Iron-catalyzed aerobic oxidative cleavage of the C-C σ-bond using air as the oxidant: Chemoselective synthesis of carbon chain-shortened aldehydes, ketones and 1,2-dicarbonyl compounds

A simple iron-catalyzed aerobic oxidative C-C σ-bond cleavage of ketones has been developed. Readily available and environmentally benign air is used as the oxidant. This reaction avoids the use of noble metal catalysts or specialized oxidants, chemoselectively yielding carbon chain-shortened aldehydes, ketones and 1,2-dicarbonyl compounds without overoxidation.