53170-19-7

Usage

Chemical Properties

Solid

InChI:InChI=1/C2H7N.ClH/c1-3-2;/h3H,1-2H3;1H/i1D3,2D3;

Upstream product

• 97941-90-7 N,N-Bis-(D₃-methyl)-p-toluolsulfonamid 
• 17829-05-9 N-nitrosodimethylamine-d₆ 

Downstream Products

• 24768-98-7 N,N-bis(trideuteriomethyl)benzamide 
• 120033-85-4 N_.N-bis(trideuteriomethyl)hydrocinnamide 
• 477909-75-4 1-(4-chloro-2-iodophenyl)-3,3-dimethyl-d6-triazene 
• 1044904-10-0 [²H₆]SKandF-S-104864 
• 1198083-68-9 [2H₆,34S]-4-nitrophenyl-S,N,N-dimethyl thiocarbamate 
• 1219802-19-3 2-chloro-N,N-dimethylacetamide-²H₆ 
• 51219-90-0 hexamethylphosphoric triamide-D₁₈ 

Relevant academic research and scientific papers

Deuterated substituted butenamide and preparation method and application thereof

The invention belongs to the field of medicines, and particularly relates to deuterated substituted butenamide and a preparation method and application thereof. The deuterated substituted butenamide is prepared from the intermediate compound shown V. Compared with the prior art, the deuterated substituted butenamide is used. The deuterated substituted butane acetamide - N - oxide has a good anti-cancer effect, and the application prospect of the medicine is increased for anti-cancer treatment drugs. , The deuterated substituted butanamide and the deuterated substituted butane acetamide - N - oxide are prepared by the process, the operation is simple, the purity is high, the three wastes are few, and the process is environment-friendly and friendly.

Method for synthesizing deuterated methylamine hydrochloride and deuterated dimethylamine hydrochloride from benzylamine protected by Boc

The invention discloses a method for synthesizing deuterated methylamine hydrochloride and deuterated dimethylamine hydrochloride by using Boc-protected benzylamine. The method mainly comprises the following step: reacting Boc-protected benzylamine serving as a raw material with a deuteration methylation reagent under alkaline conditions to generate deuterated methylamine hydrochloride and deuterated dimethylamine hydrochloride. The synthesis method provided by the invention can avoid the disadvantage that trisubstituted and tetrasubstituted methyl byproducts are easy to generate in the conventional synthesis method. Therefore, the method for preparing the deuterated methylamine hydrochloride and the deuterated dimethylamine hydrochloride has the advantages of few byproducts and easiness in purification, and has important guidance value for research and development and synthesis of deuterated drugs.

A practical synthesis of deuterated methylamine and dimethylamine

In recent years, several deuterated drugs have entered clinical trials and have been approved for use. Deuterated methylamine and dimethylamine as important intermediates play significant roles in the preparation of deuterated drugs. In this study, we have developed a new method to prepare deuterated methylamine and dimethylamine. This method employs Boc-benzylamine as the starting material and TsOCD3 as the deuterated methylation reagent. Our method gives relatively high yields and involves simple purifications, which provide a favourable supplement for the development and synthesis of deuterated drugs in the future.

Method for synthesizing deuterated dimethylamine salt with deuterated methanol

The invention discloses a method for synthesizing a deuterated dimethylamine salt by using deuterated methanol. The method comprises the following steps: (1) carrying out a reaction on a compound 1 with a sulfonyl chloride compound to obtain a compound 2; (2) carrying out a reaction on the compound 2 with R2-NH2 to obtain a compound 3; and (3) carrying out a reaction on the compound 3 with an acidto obtain the deuterated dimethylamine salt. The preparation method provided by the invention is simple and efficient, and has a good industrial application prospect.

Method for synthesizing deuterated dimethylamine salt by using halogenated deuterated methane (by machine translation)

The invention discloses a method for synthesizing deuterated dimethylamine salt with halogenated deuterated methane, which comprises the following steps: (1) reacting compound 1 with R-NH under the presence of a strong base and an inert solvent. 2 Reaction, i.e. compound 2; (2) The compound 2 is reacted with an acid to obtain a deuterated dimethylamine salt. The preparation method is simple, efficient, low in cost and good in industrial application prospect. (by machine translation)

Deuterated dimethylhydroxylamine benzoate compound and preparation method and application thereof

The invention provides a deuterated dimethylhydroxylamine benzoate compound and a preparation method and application thereof. The compound has the following structural formula as shown in the description, wherein R1, R2, R3, R4 and R5 represent hydrogen or , methoxyl or , benzyloxy or, methyl or, phenyl or, fluorine or, chlorine or, bromine or, trifluoromethyl, or oxytrifluoromethyloxy or, nitrylor, cyano or sulfonyl separately and independently; the method comprises the preparation steps that in the presence of inorganic salt, deuterated dimethylamine salt and benzoyl peroxide or a derivative of the benzoyl peroxide are protected from light react in an organic solvent, at 15-35 DEG C without light, reaction is carried out for 15-20 h, and then quenching reaction is carried out; the inorganic salt is alkali metal salt. The compound can be used as a deuterated dimethylamine agent for participating in synthsis of deuterated dimethylamine aryl compounds. A The synthesis strategy has thecharacteristics that the conditions are mild, the yield is high, the reaction rate is high, a the deuterated ratio is high, and the like.

Identification of unexpected unlabeled N,N-dimethylamide formation in the synthesis of deuterated fragment of ribociclib by a HATU-mediated coupling reaction

Starting from N,N-dimethylamine and D2O, deuterated fragment of ribociclib was synthesized for use as a mass spectroscopy internal standard. Furthermore, systematic studies on D0 (unlabeled material) formation during the amidation reaction were performed, leading to the identification of a coupling reagent, HATU (O-(7-azabenzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate), as main cause. Finally, an alternative route was designed using EDCI/HOBT as coupling reagents to produce the desired deuterated compound without D0 residue.