53173-90-3Relevant academic research and scientific papers
Intermolecular cyclocondensation of arylchloropyruvates in the synthesis of 2,3-dihydrofuran-3,5-dicarboxylic acid derivatives
Mamedov,Khafizova,Zamaletdinova,Dobrynin,Litvinov,Sinyashin
, p. 2865 - 2868 (2016/09/28)
Methyl arylchloropyruvates undergo intermolecular self-condensation in the presence of a catalytic amount of a base under high-temperature conditions (~250°C) with the formation of 3,4-diaryl-2-oxo-2,3-dihydrofuran-3,5-dicarboxylic acid derivatives.
1,2-DIAMIDO-ETHYLENE DERIVATIVES AS OREXIN ANTAGONISTS
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Page/Page column 24, (2011/11/06)
The invention relates to 1,2-diamido-ethylene derivatives of the formula (I) wherein R1, R2, R3, and A are as described in the description and their use as medicaments, especially as orexin receptor antagonists.
1,2-DIAMIDO-ETHYLENE DERIVATIVES
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Page/Page column 54-55, (2009/04/25)
The invention relates to 1,2-diamido-ethylene derivatives of the formula (I) NHNR 3 OAOR 1 R 2 (I) wherein R1, R 2, R 3, and A are as described in the description and their use as medicaments, especially as orexin receptor
Substituted benzaldehydes in the darzens condensation with alkyl dihaloacetates
Mamedov,Berdnikov,Tsuboi,Hamamoto,Komiyama,Gorbunova,Gubaidullin,Litvinov
, p. 1455 - 1463 (2007/10/03)
The Darzens reaction of dihaloacetic acid esters with aromatic aldehydes produces either arylhaloglycidic or arylhalopyruvic esters depending on the nature of the substituent in the aromatic ring. Alkyl p- methoxyphenylchloropyruvates undergo spontaneous intermolecular cyclocondensation to form pyranone or furanone derivatives depending on the character of the alkyl fragment.
Regioselective ring opening of 3-aryl-2-cyano-2-(methoxycarbonyl)oxiranes with metal halides and silica-gel-supported metal halides. Synthesis of substituted but-3-en-4-olides.
Brine, N.,Foucaud, A.
, p. 620 - 624 (2007/10/02)
Regioselective ring opening of 3-aryl-2-cyano-2-(methoxycarbonyl)oxiranes 1 with transition metal halides (copper(II) chloride, copper (II) bromide, zinc bromide, cobalt chloride and ferric chloride) and silica-gel-supported metal halides gave methyl 3-aryl-2-cyano-3-halo-2-hydroxypropanoates 5, 6 and methyl 3-aryl-3-halo-2-oxopropanoates 2, 3.The reaction of 1 in chlorobenzene under reflux with silica-gel-supported copper (II) halides gave but-3-en-4-olides 4.Key Words: methyl 3-aryl-2-cyano-3-halo-2-hydroxypropanoates; methyl 3-aryl-3-halo-2-oxopropanoates; but-3-en-4-olides.
REACTION OF METHYL DICHLOROACETATE WITH SUBSTITUTED BENZALDEHYDES UNDER THE CONDITIONS OF THE DARZENS CONDENSATION
Mamedov, V. A.,Nuretdinov, I. A.
, p. 1690 - 1692 (2007/10/02)
We have found that condensation of methyl dichloroacetate (1) with benzaldehyde, p-chloro- and p-bromobenzaldehyde in t-BuOH in the presence of t-BuOK yields methyl 3-aryl-3-chloro-2-oxopropionates (3-5).In the case of nitrobenzaldehydes the reaction prod
