53179-10-5

Usage

Uses

Antiperistaltic.

InChI:InChI=1/C30H32ClF3N2O2/c1-35(2)27(37)29(22-9-5-3-6-10-22,23-11-7-4-8-12-23)17-20-36-18-15-28(38,16-19-36)24-13-14-26(31)25(21-24)30(32,33)34/h3-14,21,38H,15-20H2,1-2H3

Upstream product

• 21928-50-7 4-[4-chloro-3-trifluoromethylphenyl]-4-piperidinol 
• 37743-18-3 N-(dihydro-3,3-diphenyl-2(3H)-furanylidene)-N-methylmethanaminium bromide 
• 50650-44-7 4-bromo-2,2-diphenylbutyric acid chloride 
• 37742-98-6 4-Bromo-2,2-diphenylbutyric acid 

Relevant academic research and scientific papers

Design and synthesis of 4-phenyl piperidine compounds targeting the mu receptor

Small molecule mu agonists based on the 4-phenyl piperidine scaffold were designed and synthesized to further investigate the therapeutic potential of loperamide analogs. The resulting compounds show excellent agonistic activity towards the human mu receptor with interesting SAR trends within the series. Small molecule mu agonists based on the 4-phenyl piperidine scaffold were designed and synthesized to further investigate the therapeutic potential of loperamide analogs. The resulting compounds show excellent agonistic activity towards the human mu receptor with interesting SAR trends within the series.

Film-forming compositions of antihyperalgesic opiates and method of treating hyperalgesic conditions therewith

Topical anti-hyperalgesic film-forming compositions and methods of using compositions for the treatment of peripheral hyperalgesia comprising: a) a compound of the formula STR1 wherein M is STR2 wherein: R, R2, R3, R4, R7, Ar1 and Ar2 are as defined in the specification; b) a film-forming polymeric material containing the hyperalgesic compound; and c) an aqueous pharmaceutically acceptable carrier.