53199-56-7Relevant academic research and scientific papers
Molecular-recognition characteristics of SAM-binding riboswitches
Lim, Jinsoo,Winkler, Wade C.,Nakamura, Shingo,Scott, Valerie,Breaker, Ronald R.
, p. 964 - 968 (2006)
(Figure Presented) A series of analogues of S-adenosylmethionine (SAM) have been used to examine the molecular-recognition characteristics of an RNA genetic element or riboswitch. Biochemical assays indicate that the riboswitch of the SAM-I class is highly selective for SAM and exhibits a pattern of molecular recognition that is distinct from that of the SAM-II class of riboswitches.
Synthesis and evaluation of analogues of S-adenosyl-L-methionine, as inhibitors of the E. coli cyclopropane fatty acid synthase
Guerard, Christine,Breard, Maud,Courtois, Fabienne,Drujon, Thierry,Ploux, Olivier
, p. 1661 - 1664 (2007/10/03)
Analogues of S-adenosyl-L-methionine were synthesized and evaluated as inhibitors of the purified E. coli cyclopropane fatty acid synthase, a model for M. tuberculosis cyclopropane synthases that are potential targets for antituberculous drugs. Our results show that the presence of the adenosine moiety, in the inhibitor, is required for strong binding, but that the sulfonium charge is less important. The best inhibitors found were S-adenosyl-L-homocysteine and its sulfoxides.
