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N-(1-phenylethyl)guanidine, also known as phenelzine or N-benzylguanidine, is an organic compound with the chemical formula C8H11N3. It is a derivative of guanidine, featuring a phenylethyl group attached to the nitrogen atom. N-(1-phenylethyl)guanidine is a monoamine oxidase inhibitor (MAOI), which means it inhibits the activity of monoamine oxidase enzymes, thus affecting the metabolism of neurotransmitters such as serotonin, norepinephrine, and dopamine. Due to its ability to influence these neurotransmitters, N-(1-phenylethyl)guanidine has been used as an antidepressant and in the treatment of certain psychiatric disorders. However, it is also known for its potential side effects and drug interactions, which require careful monitoring and management.

532-58-1

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532-58-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 532-58-1 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,3 and 2 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 532-58:
(5*5)+(4*3)+(3*2)+(2*5)+(1*8)=61
61 % 10 = 1
So 532-58-1 is a valid CAS Registry Number.

532-58-1Relevant academic research and scientific papers

A new reagent and its polymer-supported variant for the amidination of amines

Dr?ger, Gerald,Solodenko, Wladimir,Messinger, Josef,Sch?n, Uwe,Kirschning, Andreas

, p. 1401 - 1403 (2002)

New reagents for the high yielding amidination of primary and secondary amines are described. By attaching a benzyl substituent to the 3,5-dimethyl-1H-pyrazole-1-carboxamidine ring, a reagent 1 is obtained which allows easy work-up after amidination because of solubility of byproducts in organic solvents. In addition, the polystyrene-bound analogue 2 was prepared which allows amidination of various amines with high purity.

Amidination of amines under microwave conditions using recyclable polymer-bound 1H-pyrazole-1-carboxamidine

Solodenko, Wladimir,Broeker, Patrick,Messinger, Josef,Schoen, Uwe,Kirschning, Andreas

, p. 461 - 466 (2007/10/03)

A convenient one-step transformation of primary and secondary amines into the corresponding unprotected guanidines using 4-benzyl-3,5-dimethyl-1H- pyrazole-1-carboxamidine and its polymer-bound variant is described. The scopes and limitations of the method, the microwave-assistance of amidination as well as a recycling protocol are examined. Georg Thieme Verlag Stuttgart.

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