5321-46-0

Basic information

• Product Name: (4-CHLORODIPHENYL)METHYL BETA-CHLOROETHYL ETHER
• Synonyms: (4-CHLORODIPHENYL)METHYL BETA-CHLOROETHYL ETHER;(4-CHLORODIPHENYL)METHYL B HLOROETHYL ETHER;1-(4-Chlorobenzhydryl)oxy-2-chloroethane
• CAS NO: 5321-46-0
• Molecular Formula: C₁₅H₁₄Cl₂O
• Molecular Weight: 281.17706
• Mol File: 5321-46-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 173-174 °C(Press: 3 Torr)
• Appearance: /
• Density: 1.210±0.06 g/cm3(Predicted)
• CAS DataBase Reference: (4-CHLORODIPHENYL)METHYL BETA-CHLOROETHYL ETHER(CAS DataBase Reference)
• NIST Chemistry Reference: (4-CHLORODIPHENYL)METHYL BETA-CHLOROETHYL ETHER(5321-46-0)
• EPA Substance Registry System: (4-CHLORODIPHENYL)METHYL BETA-CHLOROETHYL ETHER(5321-46-0)

Safety Data

• Hazardous Substances Data: 5321-46-0(Hazardous Substances Data)

Usage

General Description

(4-CHLORODIPHENYL)METHYL BETA-CHLOROETHYL ETHER, also known as 4-Chlorodiphenylmethoxymethylchloroethane, is a chemical compound with the molecular formula C14H13Cl2O. It is a white solid that is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. (4-CHLORODIPHENYL)METHYL BETA-CHLOROETHYL ETHER is also used in the manufacturing of dyes and other organic compounds. It is a chlorinated ether, which means it contains a chlorine atom and an ether functional group. In addition, it is considered to be toxic and harmful if swallowed or inhaled, and can cause irritation to the skin and eyes. Therefore, proper handling and disposal procedures should be followed when working with this chemical.

Upstream product

• 162191-86-8 C₁₃H₁₀ClO^(1-)*Na⁽¹⁺⁾ 
• 107-06-2 1,2-dichloro-ethane 
• 119-56-2 (4-chlorophenyl)phenylmethanol 
• 107-07-3 2-chloro-ethanol 

Downstream Products

• 220329-19-1 levocloperastine fendizoate 
• 3703-76-2 Cloperastine 
• 109808-61-9 1-{2-[α-(4-chlorophenyl)benzyloxy]ethyl}piperazine 
• 138522-69-7 1-<2-(4-chlorophenyl)phenylmethoxyethyl>-4-piperidinecarbaldehyde 
• 175692-17-8 {2-[(4-Chloro-phenyl)-phenyl-methoxy]-ethyl}-methyl-amine 
• 5617-26-5 β-Morpholinoethyl-4-chlorbenzhydrylether 
• 116152-62-6 1-(4-tert-butyl-benzyl)-4-[2-(4-chloro-benzhydryloxy)-ethyl]-piperazine 

Relevant articles and documents

A left hand chlorine paipai Si Tingfenoak acid preparation method of the

The invention discloses a preparation method of levo cloperastine fendizoate, which comprises the following steps: carrying out nucleophilic substitution reaction on 4-chlorobenzhydrol and 2-chloroethanol in a benzene organic solvent, so that an intermediate product is obtained; reacting the intermediate product with piperidine, so that racemic cloperastine is obtained; resolving the racemic cloperastine by using a resolving agent in a fatty alcohol solvent, so that levo cloperastine is obtained; and carrying out salt forming reaction on the levo cloperastine and a fendizoic acid, so that levo cloperastine fendizoate is obtained, wherein the resolving agent is an R-substituted dibenzoyl-L-tartaric acid, and R refers to alkyl, alkoxy, -Cl, -F, -Br or -H. In the method provided by the invention, in a fatty alcohol solvent, an R-substituted dibenzoyl-L-tartaric acid is adopted as a resolving agent for carrying out resolving on racemic cloperastine, and the resolving yield is high, so that the obtained levo cloperastine fendizoate has high optical purity, and has a high product yield.

Synthesis and psychoanaleptic properties of new compounds structurally related to diphenhydramine

A new series of benzhydryloxyalkylpiperazines carrying a trivalent function has been synthesized and studied for its effects on the central nervous system. Most of the compounds exhibit unexpected nonamphetaminic psychoanaleptic properties. The structure-