53215-61-5

Basic information

• Product Name: 4,6(1H,5H)-Pyrimidinedione,dihydro-5-(1H-indol-3-ylmethylene)-2-thioxo-
• Synonyms: 4,6(1H,5H)-Pyrimidinedione,dihydro-5-(1H-indol-3-ylmethylene)-2-thioxo-;5-((1H-indol-3-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione;5-(1H-indol-3-ylmethylidene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
• CAS NO: 53215-61-5
• Molecular Formula: C13H9N3O2S
• Molecular Weight: 271.29446
• Mol File: 53215-61-5.mol
• Article Data: 6

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.55g/cm³
• Refractive Index: 1.784
• CAS DataBase Reference: 4,6(1H,5H)-Pyrimidinedione,dihydro-5-(1H-indol-3-ylmethylene)-2-thioxo-(CAS DataBase Reference)
• NIST Chemistry Reference: 4,6(1H,5H)-Pyrimidinedione,dihydro-5-(1H-indol-3-ylmethylene)-2-thioxo-(53215-61-5)
• EPA Substance Registry System: 4,6(1H,5H)-Pyrimidinedione,dihydro-5-(1H-indol-3-ylmethylene)-2-thioxo-(53215-61-5)

Safety Data

• Hazardous Substances Data: 53215-61-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C13H9N3O2S/c17-11-9(12(18)16-13(19)15-11)5-7-6-14-10-4-2-1-3-8(7)10/h1-6,14H,(H2,15,16,17,18,19)

Upstream product

• 487-89-8 Indole-3-carboxaldehyde 
• 504-17-6 4,6-dihydroxy-2-mercaptopyrimidine 

Relevant articles and documents

Composition for trichogenousness

The present invention relates to novel barbiturate and thiobarbiturate derivatives and a composition for promoting hair growth using the same. According to the present invention, the barbiturate and thiobarbiturate derivatives, in an animal model, have shown to promote hair growth and have excellent effects on hair growth by promoting regulation of Wnt/andbeta;-catenin and hair growth factor signaling and suppressing mechanism of apoptosis. Accordingly, the barbiturate and thiobarbiturate derivatives of the present invention may be used as a composition for promoting hair growth.COPYRIGHT KIPO 2017

Solvent-free, microwave assisted Knoevenagel condensation of novel 2,5-disubstituted indole analogues and their biological evaluation

A rapid, efficient and environmental benign methodology for the preparation of 2,5-disubstituted indole analogues is developed. 2,5-Disubstituted indole-3-carboxaldehydes (1a-c) undergo Knoevenagel condensation with barbiturates (2 & 4), thiazolidine-2,4-dione (6) and 3-methyl-1H-pyrazol- 5(4H)-one (8) in solvent-free, NH4OAc catalyzed, microwave assisted reaction. Structures of the products thus obtained were confirmed by their m.p, Elemental analysis, IR, 1H NMR, 13C NMR and Mass spectral data. The in vitro antioxidant and cytotoxic activities against three tumor cell lines were evaluated and discussed in terms of their structural differences. Among the screened compounds 9b, 9c, 7b and 5b exhibited excellent antioxidant activity. Compounds 9b, 9c and 7b have shown strong cytotoxicity among the compounds tested.

Alumina Catalyzed Synthesis of Fused Thioxopyrimidine Derivatives under Microwaves

An expeditious solventless approach for the synthesis of pyrazolino[3,4-d]/isoxazolino[3,4-d]/pyrano[2,3-d]/iminopyrimidino[4,5-d]/ thioxopyrimidino[4,5-d]/thiazino[5,4-d] pyrimidines from 2-thiobarbituric acid using supported reagents (acidic/basic alumi