53218-13-6

Basic information

• Product Name: 4-Nitrobenzeneacetic acid 4-methoxyphenyl ester
• Synonyms: 4-Nitrobenzeneacetic acid 4-methoxyphenyl ester
• CAS NO: 53218-13-6
• Molecular Formula: C₁₅H₁₃NO₅
• Molecular Weight: 287.27
• Mol File: 53218-13-6.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-Nitrobenzeneacetic acid 4-methoxyphenyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Nitrobenzeneacetic acid 4-methoxyphenyl ester(53218-13-6)
• EPA Substance Registry System: 4-Nitrobenzeneacetic acid 4-methoxyphenyl ester(53218-13-6)

Safety Data

• Hazardous Substances Data: 53218-13-6(Hazardous Substances Data)

Upstream product

• 1122-95-8 sodium 4-methoxyphenolate 
• 50434-36-1 4-nitrophenylacetyl chloride 
• 150-76-5 4-methoxy-phenol 

Downstream Products

• 104-03-0 4-nitrobenzeneacetic acid 
• 150-76-5 4-methoxy-phenol 

Relevant articles and documents

Alkaline Hydrolysis of Aryl Phenylacetates and Aryl 4-Nitrophenylacetates. Evidence consistent with an Elimination-Addition Mechanism

Hydrolysis of the substituted phenyl esters of phenylacetic acid is found to be first order each in the ester and hydroxide ion.Hydrolysis is catalysed by general bases and the catalytic coefficients for the substituted phenoxides obey the Broensted relation with β +0.49.The rate of hydrolysis of the esters of 4-nitrophenylacetic acid is independent of in the range employed.Both series of reactions exhibit low solvent isotope effect and high sensitivity to substituents in the leaving group .These datasuggest an E1cB mechanism for the hydrolysis.The keten intermediate envisaged for such a mechanism has been trapped as the anilide when the reactions are conducted in aniline buffers, without any effect on the rate of hydrolysis for variations in .An increase in the DMSO content in the solvent decreases the rate of hydrolysis of the esters of 4-nitrophenylacetic acid, which is explained by an (E1cB)anion mechanism for the hydrolysis.Transfer to aqueous DMSO results in rate accelerations for the esters of phenylacetic acid which can be accounted for by either an (E1cB)Bion pair or (E1cB)reversible mechanism for the hydrolysis.