532412-92-3Relevant academic research and scientific papers
Synthesis of acyclic bis-vinyl pyrimidines: A general route to d4T via metathesis
Ewing,Gla?on,Mackenzie,Postel,Len
, p. 941 - 945 (2007/10/03)
Unsaturated acyclic pyrimidine analogues, 1-{1-[1-(hydroxymethyl)prop-2-enyloxy]prop-2-enyl}uracil, 1-{1-[1-(hydroxymethyl)prop-2-enyloxy]prop-2-enyl}thymine and 1-{1-[1-(hydroxymethyl)prop-2-enyloxy]prop-2-enyl}cytosine having two asymmetric carbon atoms have been prepared in good yield starting from uridine and 5-methyluridine. The bis-vinyl thymine derivative underwent ring closure metathesis to give d4T, thus providing a novel synthesis of this compound.
