53242-70-9

Usage

Uses

Used in Pharmaceutical Industry:
2-HYDROXY-5-(1 H-PYRROL-1-YL)BENZOIC ACID is used as a key intermediate in the synthesis of various pharmaceuticals for its pharmacological and biological activities. Its potential antioxidant and anti-inflammatory properties make it a promising candidate for the development of new drugs to treat various diseases.
Used in Agrochemical Industry:
2-HYDROXY-5-(1 H-PYRROL-1-YL)BENZOIC ACID is used as a building block in the synthesis of agrochemicals, contributing to the development of new pesticides and other agricultural chemicals.
Used in Anticancer Research:
2-HYDROXY-5-(1 H-PYRROL-1-YL)BENZOIC ACID is used as a potential anti-cancer agent in research studies. Its pharmacological properties are being investigated for their potential to inhibit the growth and progression of cancer cells.
Used in Drug Delivery Systems:
2-HYDROXY-5-(1 H-PYRROL-1-YL)BENZOIC ACID can be used in the development of drug delivery systems to improve the bioavailability and therapeutic outcomes of pharmaceuticals. Its chemical properties may allow for the design of novel carriers and formulations to enhance the efficacy of drugs in treating various conditions.

InChI:InChI=1/C11H9NO3/c13-10-4-3-8(7-9(10)11(14)15)12-5-1-2-6-12/h1-7,13H,(H,14,15)

Upstream product

• 696-59-3 cis,trans-2,5-dimethoxytetrahydrofuran 
• 89-57-6 5-Aminosalicylic Acid 

Relevant academic research and scientific papers

Design, synthesis, and biological evaluation of N-carboxyphenylpyrrole derivatives as potent HIV fusion inhibitors targeting gp41

On the basis of the structures of small-molecule hits targeting the HIV-1 gp41, N-(4-carboxy-3-hydroxy)phenyl-2,5-dimethylpyrrole (2, NB-2), and N-(3-carboxy-4-chloro)phenylpyrrole (A1, NB-64), 42 N-carboxyphenylpyrrole derivatives in two categories (A and B series) were designed and synthesized. We found that 11 compounds exhibited promising anti-HIV-1 activity at micromolar level and their antiviral activity was correlated with their inhibitory activity on gp41 six-helix bundle formation, suggesting that these compounds block HIV fusion and entry by disrupting gp41 core formation. The structure-activity relationship and molecular docking analysis revealed that the carboxyl group could interact with either Arg579 or Lys574 to form salt bridges and two methyl groups on the pyrrole ring were favorable for interaction with the residues in gp41 pocket. The most active compound, N-(3-carboxy-4-hydroxy)phenyl-2,5-dimethylpyrrole (A12), partially occupied the deep hydrophobic pocket, suggesting that enlarging the molecular size of A12 could improve its binding affinity and anti-HIV-1 activity for further development as a small-molecule HIV fusion and entry inhibitor.

Derivatives of antiphlogistically effective carboxylic acids, their preparation and medicinal use

Compounds of Formula I STR1 wherein R1 is the residue of an antiphlogistically effective carboxylic acid of the formula R1 COOH, n is an integer 1, 2, or 3, and X is oxygen, sulfur, or optionally alkylated nitrogen have valuable antiinflammatory activity.

Synthesis and analgesic-antiinflammatory activity of some 4- and 5-substituted heteroarylsalicylic acids

We have made a series of 4- and 5-aryl- and 4- and 5-heteroarylsalicylic acid derivatives with the objective of reducing gastric irritation and increasing potency. Here we describe a series of 4- and 5-heterocyclic salicylic acids and their antiinflammatory-analgesic potencies measured in comparison to aspirin. An improvement of the therapeutic index over aspirin of 100 was achieved; however, the heterocyclic salicylic acids lacked antipyretic activity. Some physicochemical parameters which may bear on the antiinflammatory activity of these compounds are discussed.