53246-86-9Relevant articles and documents
Restricting the flexibility of crosslinked, interfacial peptide inhibitors of HIV-1 protease
Ulysse, Luckner G.,Chmielewski, Jean
, p. 3281 - 3286 (2007/10/03)
Interfacial peptides of HIV-1 protease were crosslinked with varying length alkyl-chains containing either a single cis or trans double bond, or a triple bond to remove degrees of freedom within the tethers. The synthesis of these compounds and their effects on the activity of HIV-1 protease are described.