53257-40-2

Basic information

• Product Name: 5-(2-NITROPHENYL)-2H-TETRAZOLE
• Synonyms: 5-(2-NITROPHENYL)-2H-TETRAZOLE;5-(2-Nitrophenyl) tetrazole;5-(2-NITROPHENYL)-1H-TETRAZOLE;5-(2-Nitrophenyl)-2H-Tetrazole(WXC02030)
• CAS NO: 53257-40-2
• Molecular Formula: C₇H₅N₅O₂
• Molecular Weight: 191.15
• Mol File: 53257-40-2.mol
• Article Data: 18

Chemical Properties

• Melting Point: 159.5-161 °C(Solv: water (7732-18-5))
• Boiling Point: 436.4±47.0 °C(Predicted)
• Appearance: /
• Density: 1.534±0.06 g/cm3(Predicted)
• PKA: 3.56±0.10(Predicted)
• CAS DataBase Reference: 5-(2-NITROPHENYL)-2H-TETRAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(2-NITROPHENYL)-2H-TETRAZOLE(53257-40-2)
• EPA Substance Registry System: 5-(2-NITROPHENYL)-2H-TETRAZOLE(53257-40-2)

Safety Data

• Hazardous Substances Data: 53257-40-2(Hazardous Substances Data)

Upstream product

• 612-24-8 o-nitrobenzonitrile 
• 552-89-6 2-nitro-benzaldehyde 
• 552-16-9 ortho-nitrobenzoic acid 

Downstream Products

• 63002-55-1 2-chloromethyl-5-(2-nitrophenyl)-1,3,4-oxadiazole 
• 114064-68-5 N-[2,2-Dimethyl-1-[5-(2-nitro-phenyl)-tetrazol-1-yl]-prop-(Z)-ylidene]-N'-(2,4-dinitro-phenyl)-hydrazine 

Relevant articles and documents

Fe3O4@L-lysine-Pd(0) organic–inorganic hybrid: As a novel heterogeneous magnetic nanocatalyst for chemo and homoselective [2 + 3] cycloaddition synthesis of 5-substituted 1H-tetrazoles

An efficient and sustainable synthetic protocol has been presented to synthesis and 5-substituted 1H-tetrazole privileged heterocyclic substructures. The synthetic protocol involves two-component reaction between aryl nitriles and NaN3 in water using complex of L-lysine-palladium nanoparticles (NPs) modified Fe3O4 nanoparticles as magnetically separable, recyclable, and reusable heterogeneous catalyst. Magnetically retrievable L-lysine-Pd(0) modified Fe3O4 nanoparticles were applied in [2 + 3] cycloaddition synthesis of 5-substituted 1H-tetrazoles. The advantages of this strategy include easy recovery and efficient reusability of the expensive Pd NPs, obtaining high yields of [2 + 3] cycloaddition, short reaction times, and all of the reported synthetic strategies are being performed in water as green solvent for a wide range of substrates.

A 5 - substituted four nitrogen azole compound of synthetic method (by machine translation)

The invention discloses a 5 - substituted four nitrogen azole compound of synthetic method, the synthesis method of the process is as follows: to point pen in the autoclave (I) indicated by the nitrile compounds, sodium azide, nickel ferrite and carboxylic acid ammonium ion exchange resin, added with an organic solvent to the cyclization reaction, the reaction solution after the reaction is finished filter, pickling, desolvation and heavy after crystallization, as shown in formula (II) of the 5 - substituted tetrazole compounds, yield is 85 - 95%, purity ≥ 99%; Formula (I) in the formula (II), the substituent R1 Is phenyl, substituted phenyl, C1 - C3 alkyl or amino; substituted phenyl substituent is methyl, methoxy, F or nitro. The invention of 5 - substituted tetrazole compounds synthesis method, adopt the catalytic ferrous acid nickel and carboxylic acid ammonium ion exchange resin catalyst combination, the carboxylic acid [...], not only good general the reaction substrate, the reaction yield is high, and the catalyst is easily separated and recycled, the production cost is reduced and the three waste emissions. (by machine translation)

NON-FUSED TRICYCLIC COMPOUNDS

Provided herein are compounds and pharmaceutical compositions comprising said compounds that are useful for treating cancers. Specific cancers include those that are mediated by YAP/TAZ or those that are modulated by the interaction between YAP/TAZ and TEAD.